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Curator prediction of NOT kinase activity

Midori Harris midori at
Wed Mar 8 02:57:25 PST 2006


I think there's no doubt whatsoever that this information should be 
captured. The question is what to put for reference and evidence. The best 
evidence code is probably TAS, although one could possibly also make a 
case for ISS (note that IC is restricted to inferences from other GO 
annotations, so isn't suitable).

For a reference, one possibility is to add an item to the GO_REF 
collection; then there would be an ID to plug into the file.


On Wed, 8 Mar 2006, Emily Dimmer wrote:

> Hi,
> One of our annotators, who is an expert on protein kinases, has looked 
> at the sequence of a putative protein kinase and from noticing a couple 
> of amino acids changes at its active site, has predicted that it does 
> not possess any kinase activity - she did not use any software and there 
> is no published work on this protein.
> Do you think this type of annotation should be represented in GO (we 
> feel this annotation is of high quality and adds valuable information to 
> a protein which has not yet been characterized), and if so how should 
> this annotation be shown?
> Thanks,
> Emily

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