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annotating to pseudogenes
Fiona McCarthy
fmccarthy at cvm.msstate.edu
Tue Mar 14 08:35:25 PST 2006
Hi All,
I recent found a microarray tiling paper (PMID: 15876366) where the
authors estimated that one fifth of human pseudogenes on chr22 are
potentially transcribed. It seems to me that there must be a reason for
this level of transcription, even if we don't know what it is.
I think it would be reasonable to annotate pseudogenes to GO, even if we
have to use function unknown in most cases. Otherwise, we would be
implying that *all* pseudogenes have no function, and this may not be the
case.
As for the SO definition of a pseudogene, I am not sure that I would say
that all pseudogenes are non-functional.
Fiona
AgBase Biocurator
Department of Basic Sciences
Box 6100
MS 39762-6100
Mississippi State University
USA
Tel: (+ 1) 662 325 5859
Fax: (+ 1) 662 325 1031
http://www.agbase.msstate.edu/
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