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[SO-devel] Re: annotating to pseudogenes

Bruce Aronow bruce.aronow at chmcc.org
Tue Mar 14 08:52:00 PST 2006


Hi Michael,

What about if a standard pseudogene evolves into a regulatory microRNA?
I would like to do a query for what fraction of pseudogenes are transcribed
and what fraction of them might be producing regulatory RNAs.. How would the
microRNA-generating locus be annotated to recognize that it derived from a
(likely) pseudogene origin?

Regards, Bruce 


On 3/14/06 11:37 AM, "Michael Ashburner (Genetics)" <ma11 at gen.cam.ac.uk>
wrote:

> Folks
> 
> I think that it cannot be too strongly stressed that pseudogenes
> should NOT be annotated with any GO term whatsoever, and
> certainly not unknown.
> 
> If you find something which someone says is a pseudogene but has
> a 'function' then it is NOT a pseudogene, but something else.
> This, I suspect is the case for the Tryp things, that is that
> they are what SO would call a cassette or something.
> 
> Michael
> 
> 
> 
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