Search Mailing List Archives


Limit search to: Subject & Body Subject Author
Sort by: Reverse Sort
Limit to: All This Week Last Week This Month Last Month
Select Date Range     through    

neural crest cell maturation vs. specific cell type differentiation

Doug howe dhowe at cs.uoregon.edu
Thu Mar 16 12:29:57 PST 2006


Well stated David!

The thing that I'm still not clear on then is what the "X cell 
maturation" terms are representing. 

X cell maturation would be defined as :
The process leading to the attainment of the full functional capacity of 
an X cell. This process is independent of morphogenetic change.

While X cell development would be defined as:
The process aimed at the progression of a y cell over time, from initial 
commitment of the cell to a specific fate, to the fully functional 
differentiated cell.

Can you clarify the distinction...maybe using neural crest cells as an 
example?  (sounds like a thesis defense question!)

-Doug


David Hill wrote:
> In general derivatives are considered as separate cell types. So, when 
> a neural crest cell migrates to where it is going and it is receiving 
> signals about what it is going to become, it is being committed to 
> become another cell type. This process, as GO defines it, is part of 
> the differentiation of that other cell type, not part of the 
> maturation of the neural crest cell. Although the line between when 
> one cell begins and another ends is fuzzy, if we start to try to 
> represent cell lineages in the process ontology, we run into huge 
> issues. The most obvious ones are things like "Is the differentiation 
> of a pigment cell part of the development of a neural crest cell 
> because it happens to the neural crest cell,  or is the development of 
> a neural crest cell part of the differentiation of a pigment cell 
> because it needs to happen for the pigment cell to differentiate. For 
> this reason, we keep the lineage relationships out of the ontology. 
> The lineage relationships are captured in the cell type ontology. At 
> some point, we can use the two ontologies to derive both the processes 
> and the lineages. So, for example, if a pigement cell develops only 
> from a neural crest cell in the cell ontology, then we can define the 
> process of pigment cell fate commitment as the process by which a 
> neural crest cell becomes committed to form a pigment cell.
>
> David
>
>
>
>
>
>
> Melissa Haendel wrote:
>
>> Hi, I wanted to send this set of questions separately than my 
>> previous email as I think they will require discussion.
>>
>> I need a term that represents the final stages of neural crest cell 
>> differentiation into their derivatives.  I could annotate to pigment 
>> cell differentiation, etc, but it would be better to say that all 
>> derivatives don't begin their differentiation.  Once neural crest 
>> cells begin to differentiate into their derivatives, they are no 
>> longer called neural crest cells.  So, would the term "neural crest 
>> cell maturation' with the following definition work?  "The process 
>> leading to the attainment of the full functional capacity of a neural 
>> crest cell derivative. This process is independent of morphogenetic 
>> change."  I have added the word derivative, but I don't know if this 
>> will fly.  Thought I would email the listserve for advice before 
>> making a request.
>>
>> How have any of you dealt with differentiation into derivative cell 
>> types with different names in the past?
>> Any advice is much appreciated.
>>
>> Thanks, Melissa Haendel
>
>
>



More information about the go-discuss mailing list