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Curator prediction of NOT kinase activity

Harold Drabkin hjd at
Wed Mar 8 06:04:59 PST 2006

We have several instances where there is a prediction For kinase 
activity or some activity via ip2go, but a published experiment shows 
that it does not have the activity.  Usually it turns out that it is 
because one amino acid was off, etc. Sometimes not. We keep both , since 
it is important that an experiment says otherwise.

However, in this case, you predict that it does not.  I might be 
inclined to use an  IC for this, but then we would usually point to 
another GO_ID in WITH, which we can't do here.
I would guess it's a kind of ISS to a kinase domain.


Emily Dimmer wrote:
> Hi,
> One of our annotators, who is an expert on protein kinases, has looked 
> at the sequence of a putative protein kinase and from noticing a 
> couple of amino acids changes at its active site, has predicted that 
> it does not possess any kinase activity - she did not use any software 
> and there is no published work on this protein.
> Do you think this type of annotation should be represented in GO (we 
> feel this annotation is of high quality and adds valuable information 
> to a protein which has not yet been characterized), and if so how 
> should this annotation be shown?
> Thanks,
> Emily

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