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Curator prediction of NOT kinase activity
hjd at informatics.jax.org
Wed Mar 8 06:04:59 PST 2006
We have several instances where there is a prediction For kinase
activity or some activity via ip2go, but a published experiment shows
that it does not have the activity. Usually it turns out that it is
because one amino acid was off, etc. Sometimes not. We keep both , since
it is important that an experiment says otherwise.
However, in this case, you predict that it does not. I might be
inclined to use an IC for this, but then we would usually point to
another GO_ID in WITH, which we can't do here.
I would guess it's a kind of ISS to a kinase domain.
Emily Dimmer wrote:
> One of our annotators, who is an expert on protein kinases, has looked
> at the sequence of a putative protein kinase and from noticing a
> couple of amino acids changes at its active site, has predicted that
> it does not possess any kinase activity - she did not use any software
> and there is no published work on this protein.
> Do you think this type of annotation should be represented in GO (we
> feel this annotation is of high quality and adds valuable information
> to a protein which has not yet been characterized), and if so how
> should this annotation be shown?
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