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neural crest cell maturation vs. specific cell type differentiation

J Clark jclark at
Thu Mar 16 01:59:33 PST 2006

Hi Melissa,

I think this question might do better on the development interest group 
mailing list so I am forwarding it.



Melissa Haendel wrote:

> Hi, I wanted to send this set of questions separately than my previous 
> email as I think they will require discussion.
> I need a term that represents the final stages of neural crest cell 
> differentiation into their derivatives.  I could annotate to pigment 
> cell differentiation, etc, but it would be better to say that all 
> derivatives don't begin their differentiation.  Once neural crest cells 
> begin to differentiate into their derivatives, they are no longer called 
> neural crest cells.  So, would the term "neural crest cell maturation' 
> with the following definition work?  "The process leading to the 
> attainment of the full functional capacity of a neural crest cell 
> derivative. This process is independent of morphogenetic change."  I 
> have added the word derivative, but I don't know if this will fly.  
> Thought I would email the listserve for advice before making a request.
> How have any of you dealt with differentiation into derivative cell 
> types with different names in the past?
> Any advice is much appreciated.
> Thanks, Melissa Haendel

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