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eustachi at cshl.edu
Tue Apr 24 04:39:46 PDT 2007
Yes - that's how we use them. When we want to talk about the behavior of
albumin, we would use a "binding" term.
----- Original Message -----
From: "J Clark" <jclark at ebi.ac.uk>
To: "Peter D'Eustachio" <deustp01 at med.nyu.edu>
Cc: <transport at genome.stanford.edu>
Sent: Tuesday, April 24, 2007 6:40 AM
Subject: Re: substrates
> Hi Peter,
> Thanks, I see what you mean. If I move these terms under the term
> 'transmembrane transporter activity' would you be happy with that?
> Peter D'Eustachio wrote:
>> Narrow answer: No.
>> Broad, somewhat tangential answer: yes, maybe. Biologists certainly talk
>> about serum albumin and cortisol binding globulin as "transporters" of
>> the hydrophobic small molecules that bind to them in the blood and thus
>> move from tissue to tissue, but this clearly amounts to overloading of
>> the word "transport" as far as we are concerned.
>> Peter D'Etc
>> ----- Original Message ----- From: "J Clark" <jclark at ebi.ac.uk>
>> To: <transport at genome.stanford.edu>
>> Sent: Monday, April 23, 2007 10:44 AM
>> Subject: substrates
>>> Can anybody think of any example of transport of the following
>>> substrates (belonging in the function ontology) that is not
>>> straightforward transport from one side of a membrane to another?
>>> organic acid transporter activity
>>> tricarboxylic acid transporter activity
>>> carbohydrate transporter activity
>>> alcohol transporter activity
> Gene Ontology Consortium
> EMBL-European Bioinformatics Institute
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