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dirigent proteins
Michael Ashburner (Genetics)
ma11 at gen.cam.ac.uk
Thu Jul 4 09:06:06 PDT 2002
Pankaj
I think you have made my point !
There are two draft definitions for dirigent proteins:
my general one:
definition: The orientation of free radical substrates in such a way that
only a particular stereoisomer is synthesised by an enzyme. Best characterised
as a function during lignan biosynthesis.
& your specific one:
definition: Lacking catalytic active site, the protein in the presence of an
oxidase or one electron oxidant, effects stereoselective bimolecular phenoxy
radical coupling, thus becoming a part of holozyme. Best characterised as a
function during lignan biosynthesis.
Mine would cover any dirigent protein that is known or might be discovered;
yours only those dirigent proteins involved in bimolecular phenoxy
radical coupling. Moreover, your definition is of the _protein_ and NOT
its _function_.
Michael
> From pj37 at cornell.edu Wed Jul 03 20:20:56 2002
> Envelope-to: ma11 at gen.cam.ac.uk
> Delivery-date: Wed, 3 Jul 2002 20:20:56 +0100
> Date: Wed, 03 Jul 2002 15:22:55 -0400
> From: Pankaj Jaiswal <pj37 at cornell.edu>
> Organization: Cornell University
> X-Mailer: Mozilla 4.79 [en] (Windows NT 5.0; U)
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> To: "Michael Ashburner (Genetics)" <ma11 at gen.cam.ac.uk>
> CC: geneontology-term-request at lists.sourceforge.net, rsmith at tigr.org,
> lhannick at tigr.org, midori at genome.stanford.edu,
> gofriend at genome.stanford.edu
> Subject: Re: dirigent proteins
> Content-Transfer-Encoding: 7bit
>
> Plants like
> Thuja plicata PMID: 10074466
> Linum flavum and Podophyllum peltatum PMID: 11130663
> and others, including Arabidopsis, all suggest for "a stereochemical control of
> monolignol coupling in the lignan biosynthesis". I don't think we should go for
> a generic definition.
>
> Thanks
> Pankaj
>
> "Michael Ashburner (Genetics)" wrote:
> >
> > Thanks.
> >
> > I am tempted to use a much broader definition, rather than one that
> > applies only for the dirigent protein - albeit the best characterised -
> > used for (+)-pinoresinol synthesis.
> >
> > It is clear that these proteins are _not_ enzymes.
> >
> > --
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> --
>
> ******************************************
> Pankaj Jaiswal, Ph.D.
> Postdoctoral Associate
> Dept. of Plant Breeding
> Cornell University
> Ithaca, NY-14853, USA
>
> Tel:+1-607-255-3103 / Fax:+1-607-255-6683
> E mail: pj37 at cornell.edu
> http://www.gramene.org
> ******************************************
>
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