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Reactome - Ver 15 released!

Reactome-Knowledgebase at Reactome-Knowledgebase at
Mon Sep 26 15:09:18 PDT 2005

The Reactome Knowledgebase group (Cold Spring Harbor Lab and the European 
Bioinformatics Institute) is proud to announce the release of Reactome 
Version 15 today, accessible at .

Reactome is a curated knowledgebase of biological processes in humans. It 
covers processes ranging from basic pathways of metabolism to complex events 
such as hormonal signaling and apoptosis. The information in Reactome is 
provided by expert bench biologists, and edited and managed as a relational 
database by the Reactome staff. New material is peer-reviewed and revised as 
necessary before publication to the web. 

Reactome version 15 features:
- a new module on the integration of energy metabolism, bringing the total 
number of curated reactions in the knowledgebase to 1463 and the total 
number of annotated human proteins to 1095; [that's the number of 
reference UniProt protein entities - would be 1525 if we counted each modified form of a 
protein as a separate entity]
- a revised data model improves the handling of physical entities (molecules 
and complexes) and introduces the concept of an entity set to allow the 
explicit annotation of functions shared by a family of molecules such as 
protein isoforms;
- a new strategy for electronic inference of events in model organisms from 
curated human reactions that uses OrthoMCL to identify the human : model 
organism protein orthologies for event inference. The sensitivity of 
OrthoMCL has enabled the inference of event sets for organisms ranging from 
the laboratory mouse (inferences made for 1368 of 1463 human reactions, a 
93.5% success rate) to the archaebacterium Methanococcus jannaschii (185 
events, 12.6% success).
- new web features for display of event hierarchies and the components of 
individual reactions, and an on-line editorial calendar, linked to the 
Reactome home page, that summarizes work in progress on new modules for the 

Links from and to Reactome are available for corresponding entries in NCBI Entrez 
Gene, Protein, OMIM, Ensembl genome annotations, UCSC Genome Browser,
KEGG, ChEBI  and Gene Ontology databases.

Questions or comments? Reply to this email  or please send e-mail to help at

-  Reactome Group at CSHL  and EBI

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