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Reactome version 17 released!

Reactome-Knowledgebase at Reactome-Knowledgebase at
Mon Apr 24 08:42:25 PDT 2006

The Reactome Knowledgebase group (Cold Spring Harbor Lab and the  
European Bioinformatics Institute) is proud to announce the release  
of Reactome Version 17 today,  accessible at!

Reactome is a curated knowledgebase of biological processes in  
humans. It covers processes ranging from basic pathways of metabolism  
to complex events such as hormonal signaling and apoptosis. The  
information in Reactome is provided by expert bench biologists, and  
edited and managed as a relational database by the Reactome staff.  
New material is peer-reviewed and revised as necessary before  
publication to the web. Reactome entries are linked to corresponding  
ones in NCBI EntrezGene, RefSeq, OMIM, Ensembl genome annotations,  
UCSC Genome Browser, KEGG, ChEBI and Gene Ontology (GO).

New modules include signaling cascades mediated by TGF-beta, RIG-I,  
and Toll-like receptors  3 and  4, the conjugation phase of  
xenobiotic metabolism, aspects of the metabolism of lipoproteins,  
cell cycle regulation by the anaphase-promoting complex (APC), and  
ATR activation in response to replication stress. The total number of  
curated human reactions in the knowledgebase is now 1828 and the  
total number of annotated human proteins is 1369.

New software features in version 17 include an upgraded SkyPainter  
tool, which now shows all reactions involving proteins in a user- 
specified list highlighted on the Reactome reaction map, lists these  
reactions in downloadable tabular form, and identifies pathways that  
are statistically over-represented for a list of specified proteins.  
As before, Reactome data can be exported in SMBL, Protégé, and BioPAX  
level 2 formats.

Like everything in Reactome, these downloaded and exported materials  
can be reused and redistributed freely.  For questions and comments,   
please reply to this message or write to help at

-Reactome teams at CSHL and EBI
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