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Reactome version 18 released!

Reactome-Knowledgebase at Reactome-Knowledgebase at
Thu Aug 3 07:39:31 PDT 2006

The Reactome Knowledgebase team (Lincoln Stein's group at CSHL and  
Ewan Birney's group at  European Bioinformatics Institute) is proud  
to announce the release of Reactome Version 18,  accessible at!

Reactome is a curated knowledgebase of biological processes in  
humans. It covers processes ranging from basic pathways of metabolism  
to complex events such as hormonal signaling and apoptosis. The  
information in Reactome is provided by expert bench biologists, and  
edited and managed as a relational database by the Reactome staff.  
New material is peer-reviewed and revised as necessary before  
publication to the web. Reactome entries are linked to corresponding  
ones in NCBI EntrezGene, RefSeq, OMIM, Ensembl genome annotations,  
UCSC Genome Browser, KEGG, ChEBI and Gene Ontology (GO).

New modules include the signaling cascade mediated by Toll-like  
receptor 2, Maintenance of Telomeres, Entry and Binding under HIV  
Life Cycle and the pathways of Complement Activation. Reactions and  
pathways chosen by the user are now highlighted prominently in the  
reaction map at the top of each web page. Updated release statistics  
and the Editorial Calendar are available.

A new web display feature allows the user to choose the focus species  
annotations - curated (for human) and electronically inferred (for 22  
other species). Stable identifiers have been introduced to facilitate  
the tracking of data objects over successive releases of Reactome.   
As before, Reactome data can be exported in SMBL, Protégé, and BioPAX  
level 2 formats.

Like everything in Reactome, these downloaded and exported materials  
can be reused and redistributed freely.  For questions and comments  
please reply to this message or write to help at

-Gopal Gopinathrao

Reactome, CSHL
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