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Reactome 19 released

Reactome-Knowledgebase at Reactome-Knowledgebase at
Fri Nov 17 08:02:41 PST 2006

The Reactome Knowledgebase team (Lincoln Stein's group at CSHL and  
Ewan Birney's group at  European Bioinformatics Institute) is proud  
to announce the release of Reactome Version 19,  accessible at!

Reactome is a curated knowledgebase of biological processes in  
humans. It covers processes ranging from basic pathways of metabolism  
to complex events such as hormonal signaling and apoptosis. The  
information in Reactome is provided by expert bench biologists, and  
edited and managed as a relational database by the Reactome staff.  
New material is peer-reviewed and revised as necessary before  
publication to the web. Reactome entries are linked to corresponding  
ones in NCBI, Entrez Gene, RefSeq, OMIM, Ensembl genome annotations,  
UCSC Genome Browser, KEGG, ChEBI and Gene Ontology (GO). Two way  
links between HapMap and Reactome have been enabled from this release.

Version 19 marks the completion of  "Early phase of HIV life cycle"  
with the release of Uncoating, Reverse Transcription  and Integration  
under  HIV Life Cycle. Other new modules include  HIV Vpu protein  
interactions with host  and Transport of Influenza virus RNPs into  
host nucleus under host pathogen interactions, signaling cascades  
mediated by Toll-like receptors 5,7/8,9-11, and  cell cycle events   
mediated by  p27/p21 proteins.

The standard display feature allows the user to choose the focus  
species annotations - curated (for human) and electronically inferred  
(for 22 other species).  A feature for version tracking using stable  
identifiers has been enabled. Updated release statistics and the  
Editorial Calendar are available. As before, Reactome data can be  
exported in SMBL, Protégé, and BioPAX level 2 formats.

Like everything in Reactome, these downloaded and exported materials  
can be reused and redistributed freely.  For questions and comments  
please reply to this message or write to help at

-Gopal Gopinathrao

Reactome, CSHL
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