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Notice: GO updates use of 'Unknown'

Judith Blake jblake at informatics.jax.org
Wed Oct 11 01:16:47 PDT 2006


Hello,

Please be advised that as of October 14, 2006 there will no longer be 
annotations of gene products to any "unknown":   i.e. "biological 
process unknown" (GO:0000004), "molecular function unknown" 
(GO:0005554), and "cellular component unknown" (GO:0008372).  All 
existing annotations to these terms will be moved directly to the their 
respective ROOT ontology term: "biological_process" (GO:0008150), 
"molecular function" (GO:0003674), and "cellular_component"  (GO:0005575).

This change provides a more accurate ontological representation of the 
current knowledge about the gene products.  Searching using AmiGO on the 
IDs or term names for the unknowns will return the annotations to the 
respective roots.

These terms ["biological process unknown", "molecular function unknown", 
or "cellular component unknown" ] are currently children of each 
respective aspect of the GO ontology (Process, Function, and 
Component).  These three terms were used in the past to indicate that 
our curators looked for but could not find literature demonstrating 
experimental evidence for annotation to any GO term.

Gene products, for which curators cannot find any experimental evidence 
in the literature, will simply be annotated to biological_process, 
molecular_function, and cellular_component, because they presumably are 
actually involved in some process, and provide a function, and exist as 
a cellular component.

For a fuller explanation of this improvement, please contact go-help.

-Gene Ontology Consortium



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