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Quantifying Specificity of GO Terms

Fritz Roth froth at
Tue Apr 17 18:16:23 PDT 2007

My favorite measure of GO term specificity (or 'vagueness' if you 
prefer) is the fraction of genes currently annotated with that term.

Fritz Roth

At 03:35 PM 4/17/2007, Tobias Sayre wrote:
>Dear GO Friends,
>I am working on a project that involves curation of protein data 
>that includes GO terms, and it would be very helpful if I had some 
>numerical quantification of the specificity of each term.  It is 
>possible to manually examine each term to determine this 
>specificity, but because there is a large amount of data, I would 
>like to automate the process.  I understand that there is no 
>reliable way to do this simply using the level in the DAG hierarchy, 
>but I am wondering if any of you might have a work-around.
>Tobias Sayre

Frederick P. 'Fritz' Roth, Asst. Professor,
Harvard Medical School / BCMP Dept.
250 Longwood Avenue, SGMB-322, Boston, MA 02115
phone:(617) 432-3551   mailto:fritz_roth at
fax:  (617) 432-3557

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