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[gofriends] GoPubMed (fwd)

Midori Harris midori at ebi.ac.uk
Mon Jul 2 07:28:03 PDT 2007



---------- Forwarded message ----------
Date: Mon, 02 Jul 2007 16:24:30 +0200
From: Michael Schroeder <ms at biotec.tu-dresden.de>
To: "Harris, Midori" <midori at ebi.ac.uk>
Subject: GoPubMed

Hi Midori,

a new release of http://www.GoPubMed.org is out. We have integrated Mesh 
(besides GO) and links to Wikipedia articles and to Uniprot entries for 
proteins mentioned.

If you like it, please tell your friends and help spread the word.

Cheers, Michael


SOME QUESTIONS:

Question: Which techniques are frequently used to study zebrafish development?
Question: Which processes are osteoclasts involved in?
Question: What are common histone modifications?
Question: Which diseases are associated with wnt signalling?
Question: Who publishes most at the MPI-CBG?
Question: Which diseases are asociated with HIV?
Question: Which are leading centers and scientists for liver transplantation?
Question: Which anatomical structure is affected by the bacterium helicobacter 
pylori?
Question: Which biological process is the protein Rab5 involved in and where is 
located in the cell?
Question: In which organisms is toluene degradation studied?
Question: Which enzymes are inhibited by aspirin?
Question: Which enzymes are important for congenital muscular dystrophy?


ANSWERS:

Question: Which techniques are frequently used to study zebrafish development?

Answer: Search for "zebrafish development". Under "top five and more" open
"techniques and equipment". In situ hybridization is listed
first. Clicking the term retrieves relevant articles.


Question: Which process are osteoclasts involved in?

Answer: Search for "osteoclast". Under "top five and more" open "biological
process". The first entry is "bone resorption".


Question: What are common histone modifications?

Answer: Search for "histone modification". Under "top five and more" open 
"biological sciences" and find methylation and acetylation.


Question: Which diseases are associated with wnt signalling?

Answer: Search for "wnt signalling". Under "top five and more" open "disease" 
and find "carcinoma" and many other cancer terms.


Question: Who publishes most at the MPI-CBG?

Answer: Search for "dresden[ad] planck[ad] genetics[ad]" and click on "show
statistics for these 302 articles".  Shevchenko A comes out top with
42 articles. Looks like he/she is doing work for two...


Question: Which diseases are asociated with HIV?

Answer: Type "HIV" and wait for the tree on the left to appear. Go to "top five 
& more" and click on "disease". Among others hepatitis and tuberculosis are 
mentioned. Clicking on tuberculosis retrieves the relevant articles including 
statements such as "HIV and parasitic co-infections in tuberculosis patients".


Question: Which are leading centers and scientists for liver transplantation?

Answer: Type "liver transplantation" and click on statistics for term "liver 
transplantation" at the top of the results page. Among the top authors is "P 
Neuhaus" and among the cities is "Berlin". Prof. Peter Neuhaus works at the 
Charite Hospital in Berlin, Germany, is a leading specialist in the field.


Question: Which anatomical structure is affected by the bacterium helicobacter 
pylori?

Answer: Type "helicobacter pylori", go to "top five & more" and open "anatomy" 
Among other terms "gastric mucosa" is listed. Hovering the mouse over the term 
reveals an explanation, which mentions that gastric mucosa is the lining of the 
stomach.


Question: Which biological process is the protein Rab5 involved in and where is 
located in the cell?

Answer: Type "rab5" and wait for the tree on the left to appear. Go to "top 
five & more". Click on biological process shows "endcytosis" and clicking on 
"cellular component" shows "endosomes". Hovering over the terms displays brief 
explanations of what endocytosis and endosomes are.


Question: In which organisms is toluene degradation studied?

Answer: Type "toluene degradation" and wait for the tree on the left to appear.
Go to "top five & more" and open "organisms". The bacteria pseudomonas are 
listed first. A click retrieves the relevant articles


Question: Which enzymes are inhibited by aspirin?

Answer: Type "aspirin" and wait for the tree on the left to appear. Go to 
"hierarchy of content" and then "chemicals and drugs" and "enzymes and 
co-enzymes". From there always click the top child until you reach 
"cyclooxygenase 1" and "cyclooxygenase 2". Clicking reduces the articles to a 
few which mention that aspirin inhibits cyclooxygenases.


Question: Which enzymes are important for congenital muscular dystrophy?

Answer: Type "congenital muscular dystrophy" and wait for the tree on the left 
to appear. Go to "hierarchy of content" and then "chemicals and drugs", 
"enzymes and co-enzymes", "enzymes", "transferases". There are a number of 
articles with statements such as "glycosyltransferases has revealed a novel 
mechanism for congenital muscular dystrophy."

-- 
---
Michael Schroeder, Professor in Bioinformatics

Biotec/Dept. of Computing, TU Dresden
Tatzberg 47-51, 01307 Dresden, Germany

w: www.biotec.tu-dresden.de
t: +49 351 463 400 60
f: +49 351 463 400 61
e: ms at biotec.tu-dresden.de

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