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Reactome version 20 released

Reactome-Knowledgebase at Reactome-Knowledgebase at
Thu Mar 1 11:32:54 PST 2007

Version 20 of the Reactome Knowledgebase has been released and is  
accessible at!

Reactome is a curated knowledgebase  developed and  maintained by the  
Reactome Knowledgebase team (Lincoln Stein's group at CSHL and Ewan  
Birney's group at  European Bioinformatics Institute). Reactome  
covers human biological processes ranging from basic pathways of  
metabolism to complex events such as hormonal signaling and  
apoptosis. The information in Reactome is provided by expert bench  
biologists, and edited and managed as a relational database by the  
Reactome staff. New material is peer-reviewed and revised as  
necessary before publication to the web. Reactome entries are linked  
to corresponding ones in NCBI, Entrez Gene, RefSeq, OMIM, Ensembl  
genome annotations, HapMap, UCSC Genome Browser, KEGG, ChEBI and Gene  
Ontology (GO).

New topics released in Version 20 are  Fibroblast Growth Factor  
Receptor (FGFR) signaling,  Epidermal Growth Factor Receptor (EGFR)  
signaling under signaling pathways, Gap junction trafficking under  
cell biology, and  Porphyrin metabolism, Digestion of dietary   
carbohydrate and lipid under metabolic pathways. Additional events  
for HIV  REV protein interactions, and Influenza virus RNP assembly  
have been added to corresponding infectious disease pathways.

The standard display feature allows the user to choose the focus  
species annotations - curated (for human) and electronically inferred  
(for 22 other species).  Updated release statistics and the Editorial  
Calendar are available. A SOAP based Web Services API is available  
aong with other resources to access the Reactome data from Download  
page. As before, Reactome data can be exported in SMBL, Protégé, and  
BioPAX level 2 formats.

Like everything in Reactome, these downloaded and exported materials  
can be reused and redistributed freely.  For questions and comments  
please reply to this message or write to help at

-Gopal Gopinathrao

Reactome, CSHL
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