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[gofriends] GO tool recommendations needed for demo to ~80 biologists new to GO.
edimmer at ebi.ac.uk
Fri Oct 5 10:04:45 PDT 2007
I'm looking for a tool to demonstrate during a couple of 'Introduction
to GO' talks/tutorials and I would be extremely grateful if some tool
developers/users could help me choose one.
As the audience would be mainly composed of biologists looking at
resources that work with UniProt data, I'm looking for an online tool
that clusters UniProt protein accessions to display over-representation
of GO terms. I need a simple, effective tool that:
1. is freely available
2. can accept human UniProt Accession numbers as input (e.g. Q9Y5Q8)
3. can temporarily cope with the load of ~ 40 people accessing the tool
simultaneously (if the tool can alternatively be locally installed,
thats fine too)
4. provides a simple interface and outputs a graphic showing showing
clustering of proteins around a GO node (if the tool can do more that's
fine, but for the limited time-span of the tutorials I need users to
easily understand the main idea of the tool and have results returned
5. finds statistical significance using a multiple-testing correction
6. appreciates the GO DAG, GO evidence codes, and has removed 'NOT'
annotations from any imported GO annotations.
7. provides full documentation and is fully supported
8. updates regularly with the GO gene association and OBO files (monthly
would be ideal)
If you have/use a tool which meets all these requirements, could you
please let me know?
At the bottom of this e-mail I have listed 55 human UniProt Accessions
which all have an annotation to the GO term 'Notch signaling pathway'
(GO:0007219) or one of its children, an example of one of the dataset I
might supply for the demo.
If I find more than one tool that meets the above requirements, I will
at least advertise them all, even if I can not demo each of them.
Thanks very much,
Wellcome Trust Genome Campus
Cambridge CB10 1SD, U.K.
Tel: +44 1223 494654
Fax: +44 1223 494468
email: edimmer at ebi.ac.uk
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