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[Gofriends] [Reactome-announce] Reactome version 32 released

Lisa Matthews lmatthews.nyumc at
Tue Mar 16 06:51:26 PDT 2010

Version 32 of the Reactome Knowledgebase has been released and is accessible
at **.

*New and Updated Topics*

Version 32 includes the new topic the role of CDO in Myogenesis. Topics
revised and updated with new events and/or revisions to existing events in
this release include: Synaptic Transmission (Activation of Kainate receptors
upon glutamate binding), Signaling by insulin receptor (Energy dependent
regulation of mTOR by LKB1-AMPK), DNA repair (Fanconi Anemia Pathway), Toll
Receptor Cascades (Toll Like Receptor 3(TLR3) cascade), Olfactory Signaling
Pathway, Cell Cycle Pathways, metabolic pathways for Amino Acids,
Carbohydrates, and Nucleotides, and the TCA cycle.

*About Reactome*

Reactome is a curated knowledgebase developed and maintained by the Reactome
Knowledgebase team (Lincoln Stein's group at OICR/CSHL, Ewan Birney's group
at the European Bioinformatics Institute, and Peter D'Eustachio's group at
NYU). Reactome covers human biological processes ranging from basic pathways
of metabolism to complex events such as hormonal signaling and apoptosis.
The information in Reactome is provided by expert bench biologists, and
edited and managed as a relational database by the Reactome staff. New
material is peer-reviewed and revised as necessary before publication to the
web. Reactome entries are linked to corresponding ones in NCBI, Entrez Gene,
RefSeq, OMIM, Ensembl genome annotations, HapMap, UCSC Genome Browser, KEGG,
ChEBI and Gene Ontology (GO).The web interface allows users to view the
curated annotations of human biological processes and orthology-based
electronic inferences from these annotations for 22 other species.

Updated release statistics and the Editorial Calendar are available. Data
download including database dumps and protein-protein interaction datasets
are available from the download page on the website. Reactome data can be
exported in SMBL, PSI MITAB, Protégé, and BioPAX Level 3 (Release 1.0) and
Level 2 format. Like everything in Reactome, these downloaded and exported
materials can be reused. Users can subscribe to Reactome announcement list
from the webpage **.

Reactome is seeking expert help for the curation of new modules. The
Reactome knowledgebase relies on collaborations with research biologists to
construct expert consensus views of key biological processes, and to
integrate these with other processes already in Reactome. We are seeking new
author-collaborators. If you're interested, or would like more information
about our data acquisition process, please contact us at *
editorial at*. For questions and comments please reply to this
message or write to *help at*.

*Other Reactome projects*

A preliminary list of projects now underway to extend Reactome pathway
curation spin-offs specific to non-human model organisms with contact
information is available from **.
Users interested in contributing to these endeavors or expanding them scope
of pathway annotations in the Reactome model to more organisms can write to
*help at*.

*Reactome Outreach *

Reactome Outreach takes on a variety of forms, such as public talks,
lectures, visiting schools and colleges and supporting science events.
Education is a major focus of Reactome's community outreach and aims to
inform biologists, clinicians, and bioinformaticians about what Reactome can
do. Reactome training teaches new and current users how to use Reactome
resources to help meet the efforts of their organizations, groups, or
specific audiences. Training and outreach is managed by Robin Haw; please
contact him at *outreach at* if you have an outreach request.

The development of Reactome is supported by a grant from the US National
Institutes of Health (P41 HG003751), EU grant LSHG-CT-2005-518254 "ENFIN",
and the EBI Industry Programme.
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