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[go-friends] [Reactome-announce] Version 37 of the Reactome Knowledgebase has been released.

Robin Haw Robin.Haw at oicr.on.ca
Thu Jun 23 12:51:05 PDT 2011


Version 37 includes the new pathway topic Amyloids<http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_75925.1>. Topics with new or revised events include: Immune System (NLR signaling pathways<http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_75913.1> and Class I MHC mediated antigen processing & presentation<http://reactome.oicr.on.ca/cgi-bin/eventbrowser_st_id?ST_ID=REACT_75820.1>), Synaptic Transmission (Voltage gated K+ channels<http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_75908.1>), Gene Expression<http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_71.2> (Zinc Finger transcription factors), Metabolism of amino acids and derivatives (Methionine salvage pathway<http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_75881.1>), Metabolism of RNA (Nonsense-Mediated Decay<http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_75886.1>), and Biological oxidations (Glutathione synthesis and recycling<http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_6960.4>). R Stephan<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Stephan+R%5BAuthor%5D> is our external authors in this release. P Cohen<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Cohen+P%5BAuthor%5D>, T Elliot<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Elliot+T%5BAuthor%5D>, E James<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=James+E%5BAuthor%5D>, T Kufer<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Kufer+T%5BAuthor%5D>, G Neu-Yilik<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Neu-Yilik+G%5BAuthor%5D>, G Perry<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Perry+G%5BAuthor%5D>, F Rauscher<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Rauscher+F%5BAuthor%5D>, and J Schimenti<http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=DetailsSearch&Term=Schimenti+J%5BAuthor%5D> are our external reviewers. Three summer students are working with Reactome developers as part of the Google Summer of Code (GSoC) 2011 program. Two recent publications describe prognostic markers and potential therapeutic targets in adenocarcinoma<http://www.ncbi.nlm.nih.gov/pubmed/21593195> and a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening<http://www.ncbi.nlm.nih.gov/pubmed/21397858>.

A full description of the new and updated pathways available on the Reactome website at http://www.reactome.org.

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute. Freely available to everyone worldwide, the Reactome database offers pathway data encapsulating areas of human biology ranging from metabolism to complex events such as GPCR signaling and apoptosis, extracted from the published literature by Reactome curatorial staff and cross-referenced to a wide range of standard biological databases. Reactome data and software are distributed under the terms of the Creative Commons Attribution 3.0 Unported License.

For more information contact:
Robin Haw
Email: help at reactome.org<mailto:help at reactome.org>
Tel: 647-260-7985
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