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[go-friends] [Reactome-announce] Reactome Version 40 released

Robin Haw Robin.Haw at
Fri Mar 23 08:36:11 PDT 2012

The pathway Extracellular matrix organization<> is new and includes Activation of Matrix Metalloproteinases<>. Topics with new or revised events include Immune System (Regulation of complement cascade<>, Trafficking and processing of endosomal TLR<>, Signaling by B cell receptor<>, and DAI mediated induction of type I IFNs<>), Metabolism of proteins, (Mitochondrial Protein Import<>), Signal transduction (Signaling by Hippo<>, Signaling by Notch<>), Circadian clock<>, and Gene Expression (Regulatory RNA Pathways<>). Sean Egan<> is our external author. DT Bradley <> , G Butler<>, F Delaunay<>, HS Earp<>, T Endo<>, L Fraczek<>, CA Leifer<>, AM Misior<>, ES Mocarski<>, CM Overall<>, FJ Rauscher<>, WA Rose<>, M Sudol<>, Y Tomari<>, JW Upton<>, and J Wienands<> are our external reviewers. We have created short Reactome tutorial videos<> that demonstrate the use of our navigation and analysis tools. New ones for this release are Pathway Browser<>, Pathway Analysis<>, and Expression Analysis<>. Others will be added to the Reactome YouTube Channel<> as they become available. Our SBML<> export (available here<>) has been enriched with a wide variety of additional annotations, including SBO<> terms.  We have switched from using the layout extension to embedded SBGN<> for conveying pathway layout.

A full description of the new and updated pathways is available on the Reactome website at<>

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute. Freely available to everyone worldwide, the Reactome database offers pathway data encapsulating areas of human biology ranging from metabolism to complex events such as GPCR signaling and apoptosis, extracted from the published literature by Reactome curatorial staff and cross-referenced to a wide range of standard biological databases. Reactome data and software are distributed under the terms of the Creative Commons Attribution 3.0 Unported License.

For more information contact:

Robin Haw

Email: help at<>

Tel: 647-260-7985
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