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[go-friends] UniProt-GOA release [2012-09-04]

Tony Sawford tonys at ebi.ac.uk
Tue Sep 4 08:00:14 PDT 2012


UniProt-GOA release: 04 September 2012
======================================

UniProt-GOA (UniProt GO Annotation) is a project run by the UniProt
group that provides assignments of gene products to the Gene Ontology
(GO) resource.

The data can be obtained via:

          EBI FTP: ftp://ftp.ebi.ac.uk/pub/databases/GO/goa/

          EBI SRS: http://srs.ebi.ac.uk. Search GOA data library

          GO FTP: ftp://ftp.geneontology.org/pub/go/gene-associations/

          GO CVS: http://www.geneontology.org/GO.CVS.help.html

For further information read: http://www.ebi.ac.uk/GOA or contact
goa at ebi.ac.uk.

Latest News
===========

Reduced redundancy of InterPro GO annotations.

In this release we have altered our display of InterPro2GO annotations
in order to reduce the redundancy. This has resulted in a large
reduction in the number of GO annotations from InterPro from 83 million
to around 51 million, a decrease of approximately 32 million annotations.

Previously, when different InterPro domains predict the same GO ID to
the same protein, we displayed these as separate annotations. We have
changed this so that all the InterPro domains that predict the same GO
ID for the same protein will be piped together in the 'with' field of a
single annotation line, ensuring no loss of data.

An example;
Previously there were 4 annotations linking GO:0030170 to A0A000 from
InterPro2GO:

A0A000 GO:0030170 pyridoxal phosphate binding F IEA InterPro:IPR004839
20120512 InterPro
A0A000 GO:0030170 pyridoxal phosphate binding F IEA InterPro:IPR010961
20120512 InterPro
A0A000 GO:0030170 pyridoxal phosphate binding F IEA InterPro:IPR015421
20120512 InterPro
A0A000 GO:0030170 pyridoxal phosphate binding F IEA InterPro:IPR015422
20120512 InterPro

This data will instead be represented as:

A0A000 GO:0030170 pyridoxal phosphate binding F IEA
InterPro:IPR004839|InterPro:IPR010961|InterPro:IPR015421|InterPro:IPR015422
20120512 InterPro


Regards,
UniProt-GOA Production


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