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[go-friends] Reactome Announcement: Version 45 of Reactome Knowledgebase has been released.

Robin Haw Robin.Haw at
Mon Jun 24 11:58:13 PDT 2013

New Pathway topics include: Reproduction (Fertilization<>) and SUMOylation (Processing and activation of SUMO<>). Topics with new or revised events include Apoptosis (Extrinsic Pathway for Apoptosis<>), Binding and Uptake of Ligands by Scavenger Receptors<>, Cell Cycle (Nuclear Pore Complex (NPC) Disassembly<>), Disease (Assembly Of The HIV Virion<> and Budding and maturation of HIV virion<>), Extracellular matrix organization (Non-integrin membrane-ECM interactions<> and ECM proteoglycans)<>, Immune System (Complement cascade<>, Cytosolic sensors of pathogen-associated DNA<>, and Fc epsilon receptor (FCERI) signaling<>), Metabolism (Metabolism of vitamins and cofactors<>), Signal transduction (The phototransduction cascade<>, Signaling by NOTCH2<>, Signaling by GPCR<>, and Signaling by Wnt<>).

R Belew<> and A Niarakis<> are our external authors. W Antonin<>, M Boutros<>, S Boyle<>, DT Bradley<>, M Dubé<>, EJ Fuentes<>, AK Garg<>, MX Ilagan<>, L Jin<>, P Lishko<>, CL Makino<>, N Venkatesan<>, C Neyen<>, C Pop<>, S Ricard-Blum<>, R Roncagalli<>, GS Salvesen<>, and J Wu<> are our external reviewers.

A full description of the new and updated pathways is available on the Reactome website at<>
Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute. Freely available to everyone worldwide, the Reactome database offers pathway data encapsulating areas of human biology ranging from metabolism to complex events such as FGFR signaling, apoptosis and disease, extracted from the published literature by Reactome curatorial staff and cross-referenced to a wide range of standard biological databases. Reactome data and software are distributed under the terms of the Creative Commons Attribution 3.0 Unported License.

For more information contact:
Robin Haw
Email: help [at]
Tel: 647-260-7985
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