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[go-friends] Reactome Announcement: Version 44 of Reactome Knowledgebase has been released.

Robin Haw Robin.Haw at
Thu Mar 21 21:02:04 PDT 2013

New to Reactome is Binding and Uptake of Ligands by Scavenger Receptors. <> Topics with new or revised events include Immune system (Fcgamma receptor (FCGR) dependent phagocytosis<>), Cell Cycle (Resolution of Sister Chromatid Cohesion<>, Regulation of PLK1 Activity at G2/M Transition<>, Nuclear envelope breakdown<>, and Initiation of Nuclear Envelope Reformation<>), Extracellular matrix organization (Fibronectin matrix formation<> and Elastic fibre formation<>), Metabolism (Ubiquinol biosynthesis<> and cytosolic-nuclear iron-sulfur cluster biogenesis)<>, Signal Transduction (Signaling by TGF-beta Receptor Complex<>, Signaling by NOTCH2<>, and Visual phototransduction)<>, Transmembrane transport of small molecules (Stimuli-sensing channels)<>, and Disease (Diseases associated with visual transduction<>, and Signaling by NOTCH1 in cancer)<>. New pathway illustrations for this release include Apoptosis Extrinsic pathway<> and Trafficking<> and processing of endosomal TLRs<>. R Lill<> is our external author. J Avruch<>, W Blaner<>, V Fiorito<>, L He<>, M Kawamukai<>, I Mattaj<>, S Moestrup<>, J Parkinson<>, F Rauscher<>, D Reinhardt<>, C Rosales<>, Y Tanno<>, E Tolosano<>, EJ Uringa<>, Y Watanabe<>, and R Weil<> are our external reviewers. Plant Reactome<>, an integrated analysis and visualization platform for plant metabolic and regulatory pathways and networks has been released. Reactome is actively soliciting feedback through a User Survey<> in order to assess community needs.

A full description of the new and updated pathways is available on the Reactome website at<>

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute. Freely available to everyone worldwide, the Reactome database offers pathway data encapsulating areas of human biology ranging from metabolism to complex events such as FGFR signaling, apoptosis and disease, extracted from the published literature by Reactome curatorial staff and cross-referenced to a wide range of standard biological databases. Reactome data and software are distributed under the terms of the Creative Commons Attribution 3.0 Unported License.

For more information contact:
Robin Haw
Email: help [at]
Tel: 647-260-7985
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