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[go-friends] Reactome Announcement: Version 46 of Reactome Knowledgebase has been released.

Robin Haw Robin.Haw at oicr.on.ca
Fri Sep 27 13:57:08 PDT 2013


Topics with new or revised events include Disease (Defects in biotin metabolism<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_169238.1>, Defects in cobalamin (B12) metabolism<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_169429.1> and TGF-beta receptor complex signaling in cancer<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=%20REACT_169122.1>), Signal transduction (Signaling by Leptin<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_169118.1>), Extracellular matrix organization (Degradation of the extracellular matrix<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_118572.5>, Laminin interactions<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_169262.1>, and Integrin cell surface interactions)<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_13552.3>, Transmembrane transport of small molecules (TRP channels<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_169333.1>), Cell cycle (Regulation of PLK1 activity at G2/M transition<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_160315.3>), and Cellular response to stress (Cellular senescence<http://reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_169274.1>). Rosemary J Akhurst<http://www.ncbi.nlm.nih.gov/pubmed?term=Rosemary%20J%20Akhurst%5BAuthor%5D>, Wytse Bruinsma<http://www.ncbi.nlm.nih.gov/pubmed?term=Wytse%20Bruinsma%5BAuthor%5D>, Lei He<http://scholar.google.co.uk/citations?user=wstFGeYAAAAJ>, Dominique Meyer<http://www.ncbi.nlm.nih.gov/pubmed?term=Dominique%20Meyer%5BAuthor%5D>, Steven W Polyak<http://www.adelaide.edu.au/directory/steven.polyak>, Sylvie Ricard-Blum<http://www.ncbi.nlm.nih.gov/pubmed?term=Sylvie%20Ricard-Blum%5BAuthor%5D>, Shamith Samarajiwa<http://www.ncbi.nlm.nih.gov/pubmed?term=Shamith%20Samarajiwa%5BAuthor%5D>, Thomas Scherer<http://www.ncbi.nlm.nih.gov/pubmed?term=Scherer%20T%5BAuthor%5D&cauthor=true&cauthor_uid=23391243>, and David Watkins<http://www.ncbi.nlm.nih.gov/pubmed/?term=David+Watkins> are our external reviewers. Plant Reactome<http://plantreactome.oicr.on.ca/> has released a new batch of rice pathways associated with cofactor biosynthesis<http://plantreactome.oicr.on.ca/entitylevelview/PathwayBrowser.html#DB=test_slice_oryza_sativa_05&FOCUS_SPECIES_ID=186860&FOCUS_PATHWAY_ID=2867929&ID=2867929>, hormone biosnythesis<http://plantreactome.oicr.on.ca/entitylevelview/PathwayBrowser.html#DB=test_slice_oryza_sativa_05&FOCUS_SPECIES_ID=186860&FOCUS_PATHWAY_ID=2744341&ID=2744341>, and fatty acids & lipids biosynthesis<http://plantreactome.oicr.on.ca/entitylevelview/PathwayBrowser.html#DB=test_slice_oryza_sativa_05&FOCUS_SPECIES_ID=186860&FOCUS_PATHWAY_ID=3906998&ID=3906998>. Examples include: pyridoxamine anabolism<http://plantreactome.oicr.on.ca/entitylevelview/PathwayBrowser.html#DB=test_slice_oryza_sativa_05&FOCUS_SPECIES_ID=186860&FOCUS_PATHWAY_ID=1119303&ID=1119303>, ABA biosynthesis and mediated signaling<http://plantreactome.oicr.on.ca/entitylevelview/PathwayBrowser.html#DB=test_slice_oryza_sativa_05&FOCUS_SPECIES_ID=186860&FOCUS_PATHWAY_ID=3899368&ID=3899368> and glycolipid desaturation<http://plantreactome.oicr.on.ca/entitylevelview/PathwayBrowser.html#DB=test_slice_oryza_sativa_05&FOCUS_SPECIES_ID=186860&FOCUS_PATHWAY_ID=1119300&ID=1119300>. The Reactome FI plugin<http://wiki.reactome.org/index.php/Reactome_FI_Cytoscape_Plugin>, which was designed to find network patterns related to cancer and other types of diseases within a gene list, has been upgraded to support Cytoscape<http://cytoscape.org/> v3, and is now available at the Cytoscape app store<http://apps.cytoscape.org/apps/reactomefiplugin>.

A full description of the new and updated pathways is available on the Reactome website at http://www.reactome.org<http://www.reactome.org/>
Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute. Freely available to everyone worldwide, the Reactome database offers pathway data encapsulating areas of human biology ranging from metabolism to complex events such as FGFR signaling, apoptosis and disease, extracted from the published literature by Reactome curatorial staff and cross-referenced to a wide range of standard biological databases. Reactome data and software are distributed under the terms of the Creative Commons Attribution 3.0 Unported License.

For more information contact:
Robin Haw
Email: help [at] reactome.org<http://reactome.org/>
Tel: 647-260-7985<tel:647-260-7985>

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