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[go-friends] Reactome Announcement: Version 48 of Reactome Knowledgebase has been released.

Robin Haw Robin.Haw at
Wed Apr 2 20:42:10 PDT 2014

New in V48 is Organelle biogenesis (Mitochondrial biogenesis<>). Topics with new or updated pathways include: Cell cycle (Depolymerisation of the nuclear lamina<,69278,68886>), Cellular responses to stress (Cellular responses to heat stress)<>, Development (Transcriptional regulation of pluripotent stem cells)<>, Disease (Glycogen storage diseases (Myoclonic epilepsy of Lafora)<,3229121> and Neurotoxicity of clostridium toxins<>), Gene expression (Epigenetic regulation of gene expression<>), Metabolism of proteins (O-glycosylation of TSR domain-containing proteins<,597592> and Sialic acid metabolism<,597592,446203,446193,446219>), and Signal transduction (TCF-dependent signaling in response to WNT)<,195721>. The Gallus gallus pathway Innate immune system has been updated to include Complement cascade<>. Luciano Di Croce<>, Matyas Gorjanacz<>,Ingrid Grummt<>, Angela M Lezza<>, Juan F Medrano<>, Mridul Mukherji<>, Bibhusita Pani<>,Bartholomew Pederson<>, Gerd Pfeifer<>, Nishani Rajakulendran<>, Yih-Horng Shiao<>, Renee van Amerongen<>, Renate Voit<>, Jianlong Wang<>, and Saumya Wickramasinghe<> are our external reviewers.

A full description of the new and updated pathways is available on the Reactome website at<>

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute. Freely available to everyone worldwide, the Reactome database offers pathway data encapsulating areas of human biology ranging from metabolism to complex events such as FGFR signaling, apoptosis and disease, extracted from the published literature by Reactome curatorial staff and cross-referenced to a wide range of standard biological databases. Reactome data and software are distributed under the terms of the Creative Commons Attribution 3.0 Unported License.

For more information contact:
Robin Haw
Email: help [at]
Tel: 647-260-7985
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