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[go-friends] Reactome Announcement: Version 55 of Reactome Knowledgebase has been released.

Robin Haw Robin.Haw at
Tue Dec 22 20:33:09 PST 2015

[Reactome News Announcement]<>


New Pathways for Version 55. Topics with new or revised pathways include: Developmental biology (Activation of anterior HOX genes in hindbrain development during early embryogenesis<>), Disease (ABC transporter diseases<>), Gene expression (B-WICH complex positively regulates rRNA expression and tRNA processing<>), Hemostasis (updated Cell surface interaction at the vascular wall<> and GPVI-mediated activation cascade<>), Immune system (IL-6 family<> signaling and Regulation of BCR signaling by CD22<>), Metabolism (Response to metal ions,<> Selenoamino acid synthesis and metabolism <> as well as updates to Complex I biogenesis<> and Metabolism of fat-soluble vitamins<>). Metabolism of proteins has been updated to include Protein repair<> as well as revisions to Amyloid fiber formation<> and SUMOylation<>. Cellular responses to stress includes an update to Macroautophagy<>, Muscle contraction has been expanded to include Cardiac conduction<>. Signal transduction includes updates to the RHO GTPases Activate NADPH Oxidases pathway,<> and Vesicle-mediated transport now covers COPI-mediated anterograde traffic<>.

Our external author is René Rezsohazy<>. Jan-Willem Akkerman<>, Sílvia Atrian<>, Angela Bachi<>, Francesco Blasi<>, Gianni Colotti<>, Giuseppe Filosa<>, David Fisher<>, Yaron Galanty<>, Nayef Jarrous<>, Daniel Klionsky<>,Taco Kuijpers<>, Rakesh Kumar<>, Birgit Meldal<>, Masashi Narazaki<> , James Paulson<>, Piergiorgio Percipalle<>, George Perry<>, Chris Powell<>, Mark Rush<>, Suneet Shukla<>, Guntram Suske<>, Tsutomu Suzuki<>, Toshio Tanaka<>, and Xiang-Dong Zhang<> are our external reviewers.

Reactome comprises 9,052 human reactions organized into 1,937 pathways involving 8,840 proteins encoded by 8,695 different human genes, and 1,618 small molecules. These annotations are supported by 21,604 literature references. We have projected these reactions onto 103,639 orthologous proteins, creating 20,674 orthologous pathways in 19 non-human species.

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute.Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on theReactome website<>.

Follow us on Twitter: @reactome<> to get frequent updates about new and updated pathways, feature updates, and more!

For more information please contact Robin Haw<mailto:robin.haw at> (Tel: 647-260-7985).

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