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[go-friends] Reactome Announcement: Version 53 of Reactome Knowledgebase has been released

Robin Haw Robin.Haw at oicr.on.ca
Thu Jul 16 09:13:50 PDT 2015


[Reactome News Announcement]<http://www.reactome.org/>

[http://reactomedev.oicr.on.ca/wordpress/wp-content/uploads/2015/07/illustration_senescence_oxidative_stress_72-600x395.png]<http://www.reactome.org/PathwayBrowser/#R-HSA-2559580.1>


New Pathways for Version 53. Signal transduction pathways have been updated to include mTOR signaling<http://www.reactome.org/PathwayBrowser/#R-HSA-165159>, MAPK6/MAPK4 signaling<http://www.reactome.org/PathwayBrowser/#R-HSA-5687128>, the RAF/MAPK pathway<http://www.reactome.org/PathwayBrowser/#R-HSA-5673001> and Deactivation of the beta-catenin transactivating complex<http://www.reactome.org/PathwayBrowser/#R-HSA-3769402>.

New immune system pathway include the TNFRSF mediated non-canonical NF-kB pathway<http://www.reactome.org/PathwayBrowser/#R-HSA-5668541> and Immunoregulatory interactions between Lymphoid and a non-Lymphoid cells<http://www.reactome.org/PathwayBrowser/#R-HSA-198933>.

New disease pathways are Diseases associated with glycosylation precursor biosynthesis<http://www.reactome.org/PathwayBrowser/#R-HSA-5609975> and ABC transporter diseases<http://www.reactome.org/PathwayBrowser/#R-HSA-5619084>.

Other revised topics include Cellular responses to stress (Macroautophagy<http://www.reactome.org/PathwayBrowser/#R-HSA-1632852>), Chromatin organization (HDMs demethylate histones<http://www.reactome.org/PathwayBrowser/#R-HSA-3214842>) and developmental biology (LGI-ADAM interactions<http://www.reactome.org/PathwayBrowser/#R-HSA-5682910>).

New pathway Illustrations are available for Cellular Senescence<http://www.reactome.org/PathwayBrowser/#R-HSA-2559583>, Oncogene Induced Senescence<http://www.reactome.org/PathwayBrowser/#R-HSA-2559585>, Oxidative Stress Induced Senescence<http://www.reactome.org/PathwayBrowser/#R-HSA-2559580>, DNA Damage/Telomere Stress Induced Senescence,<http://www.reactome.org/PathwayBrowser/#R-HSA-2559586> Senescence-Associated Secretory Phenotype (SASP).<http://www.reactome.org/PathwayBrowser/#R-HSA-2559582>

Alexander Barrow<http://www.ncbi.nlm.nih.gov/pubmed?term=Alexander%20Barrow%5BAuthor%20-%20Full%5D>, Sharon A Tooze<http://www.ncbi.nlm.nih.gov/pubmed?term=Sharon%20A%20Tooze%5BAuthor%20-%20Full%5D>, Vincent Harley<http://www.ncbi.nlm.nih.gov/pubmed?term=Vincent%20%20Harley%5BAuthor%20-%20Full%5D>, Richard Hopkinson<http://www.ncbi.nlm.nih.gov/pubmed?term=Richard%20Hopkinson>, Simon Mathien<http://www.ncbi.nlm.nih.gov/pubmed?term=Simon%20%20Mathien%5BAuthor%20-%20Full%5D>, Dies Meijer<http://www.ncbi.nlm.nih.gov/pubmed?term=Dies%20Meijer%5BAuthor%20-%20Full%5D>, Sylvain Meloche<http://www.ncbi.nlm.nih.gov/pubmed/?term=Meloche%20S%5BAuthor%5D&cauthor=true&cauthor_uid=24475167>, Ugo Moens<http://www.ncbi.nlm.nih.gov/pubmed/?term=Moens%20U%5BAuthor%5D&cauthor=true&cauthor_uid=24651460>, Karobi Moitra<http://www.ncbi.nlm.nih.gov/pubmed/?term=Moitra%20K%5BAuthor%5D&cauthor=true&cauthor_uid=21942345>, Akhil Rajput<http://www.ncbi.nlm.nih.gov/pubmed/?term=Rajput%20A%5BAuthor%5D&cauthor=true&cauthor_uid=12110139>, Robert Roskoski<http://www.brimr.org/>, Christopher Schofield<http://www.ncbi.nlm.nih.gov/pubmed?term=Schofield%20CJ%5BAuthor%5D&cauthor=true&cauthor_uid=24859458>, Ole-Morten Seternes<http://www.ncbi.nlm.nih.gov/pubmed?term=Ole-Morten%20Seternes%5BAuthor%20-%20Full%5D>, Mathilde Soulez<http://www.ncbi.nlm.nih.gov/pubmed?term=Mathilde%20Soulez%5BAuthor%20-%20Full%5D>, Dorothe Spillmann<http://www.imbim.uu.se/Research/Biochemistry+and+Molecular+Cell+Biology+/Spillmann_Dorothe/?languageId=1>, David J Timson<http://www.ncbi.nlm.nih.gov/pubmed?term=David%20J%20Timson%5BAuthor%20-%20Full%5D>, Richard Virgen-Slane<http://www.ncbi.nlm.nih.gov/pubmed?term=Richard%20%20Virgen-Slane%5BAuthor%20-%20Full%5D>, Louise Walport<http://www.ncbi.nlm.nih.gov/pubmed?term=Louise%20Walport%5BAuthor%5D>, Carl F Ware<http://www.ncbi.nlm.nih.gov/pubmed?term=Carl%20F%20Ware%5BAuthor%20-%20Full%5D>, and Fried Zwartkruis<http://www.ncbi.nlm.nih.gov/pubmed?term=Fried%20%20Zwartkruis%5BAuthor%20-%20Full%5D> are our external reviewers.

As of Version 53, Reactome comprises 8,369 human reactions involving the 8,360 protein products of 8,232 human genes, and 1,454 small molecules. These reactions are organized into 1,762 pathways, supported by 19,562 PubMed literature references. We have projected these reactions onto 98,602 orthologous proteins, creating 19,039 orthologous pathways in 18 model organisms.

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute.Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the Reactome website<http://www.reactome.org/>.

Follow us on Twitter: @reactome<https://twitter.com/reactome> to get frequent updates about new and updated pathways, feature updates, and more!

For more information please contact Robin Haw<mailto:robin.haw at oicr.on.ca> (Tel: 647-260-7985).





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