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[go-friends] Reactome Announcement: Version 54 of Reactome Knowledgebase has been released

Robin Haw Robin.Haw at oicr.on.ca
Sun Oct 4 16:55:28 PDT 2015


[Reactome News Announcement]<http://www.reactome.org/>

[DNA Repair]<http://reactome.org/PathwayBrowser/#R-HSA-73894.2>


New Pathways for Version 54. The topic Mitophagy<http://reactome.org/PathwayBrowser/#DIAGRAM=5205647> has been added. New disease pathways include SLC transporter disorders<http://reactome.org/PathwayBrowser/#DIAGRAM=5619102&PATH=1643685,5619115>, Essential pentosuria<http://reactome.org/PathwayBrowser/#DIAGRAM=5662853&PATH=1643685,5668914,5663084>, Diseases associated with surfactant metabolism<http://reactome.org/PathwayBrowser/#DIAGRAM=5687613&PATH=1643685,5668914>,  Pentose phosphate pathway disease<http://reactome.org/PathwayBrowser/#DIAGRAM=6791465&PATH=1643685,5668914,5663084>, and Glycogen storage diseases<http://reactome.org/PathwayBrowser/#DIAGRAM=3229121&PATH=1643685,5668914,5663084>. Updated DNA repair pathways include Double-strand break repair<http://reactome.org/PathwayBrowser/#DIAGRAM=5693532&PATH=73894>, Nucleotide excision repair<http://reactome.org/PathwayBrowser/#DIAGRAM=5696398&PATH=73894>, and the Fanconi anemia pathway<http://reactome.org/PathwayBrowser/#DIAGRAM=6783310&PATH=73894>. Gene expression now covers tRNA processing<http://reactome.org/PathwayBrowser/#DIAGRAM=72306&PATH=74160> and immune system annotations have been expanded to include MAP3K8 (TPL2)-dependent MAPK1/3 activation<http://reactome.org/PathwayBrowser/#DIAGRAM=5684264&PATH=168256,1280215,449147,446652> as well as updates to the Immunoregulatory interactions between a lymphoid and a non-lymphoid cell<http://reactome.org/PathwayBrowser/#DIAGRAM=198933&PATH=168256,1280218> pathway. Under Metabolism, Surfactant metabolism<http://reactome.org/PathwayBrowser/#DIAGRAM=5683826&PATH=392499> and Catabolism of glucuronate to xylulose-5-phosphate<http://reactome.org/PathwayBrowser/#DIAGRAM=71387&ID=5661270&PATH=1430728> have been added and Fructose metabolism<http://reactome.org/PathwayBrowser/#DIAGRAM=71387&ID=5652084&PATH=1430728> has been revised. Metabolism of proteins includes additions to the Amyloid formation<http://reactome.org/PathwayBrowser/#DIAGRAM=977225&PATH=392499> pathway. Signal transduction includes updates to the TNF signaling<http://reactome.org/PathwayBrowser/#DIAGRAM=75893&PATH=162582,73887> pathway and Vesicle-mediated transport now covers Cargo concentration in the ER<http://reactome.org/PathwayBrowser/#DIAGRAM=5694530&PATH=5653656,199991,199977> as well as additions to COPII (Coat protein 2) mediated vesicle transport.<http://reactome.org/PathwayBrowser/#DIAGRAM=204005&PATH=5653656,199991,199977>

New pathway Illustrations are available for Asparagine N-linked glycosylation<http://reactome.org/PathwayBrowser/#DIAGRAM=446203&PATH=392499,597592> and DNA repair<http://reactome.org/PathwayBrowser/#DIAGRAM=73894>.

Alexander Barrow<http://www.ncbi.nlm.nih.gov/pubmed?term=Alexander%20%20%20Barrow%5BAuthor%20-%20Full%5D>, James Borowiec<http://www.ncbi.nlm.nih.gov/pubmed/?term=James+Borowiec%5BAuthor+-+Full%5D>, Stefan Bröer<http://www.ncbi.nlm.nih.gov/pubmed/?term=Br%C3%B6er%20S%5BAuthor%5D&cauthor=true&cauthor_uid=26240152>, Daniel Chauss<http://www.ncbi.nlm.nih.gov/pubmed/?term=Chauss%20D%5BAuthor%5D&cauthor=true&cauthor_uid=20888813>, Katie DeCicco-Skinner<http://www.ncbi.nlm.nih.gov/pubmed/?term=DeCicco-Skinner%20KL%5BAuthor%5D&cauthor=true&cauthor_uid=25225985>, Maria Fousteri<http://www.ncbi.nlm.nih.gov/pubmed/?term=Maria+Fousteri>, Kasper Fugger<http://www.ncbi.nlm.nih.gov/pubmed/?term=Kasper+Fugger>, Marc Kantorow<http://www.ncbi.nlm.nih.gov/pubmed?term=Marc%20Kantorow%5BAuthor%20-%20Full%5D>, Louis Levinger<http://www.ncbi.nlm.nih.gov/pubmed?term=Louis%20Levinger%5BAuthor%20-%20Full%5D>, Yuri Motorin<http://www.ncbi.nlm.nih.gov/pubmed?term=Yuri%20%20Motorin%5BAuthor%20-%20Full%5D>, and Harald Wajant<http://www.ncbi.nlm.nih.gov/pubmed?term=Harald%20Wajant%5BAuthor%20-%20Full%5D> are our external reviewers. João Ribeiro<http://www.ncbi.nlm.nih.gov/pubmed/?term=Ribeiro%20JM%5BAuthor%5D&cauthor=true&cauthor_uid=25692488> and José Carlos Cameselle<http://www.ncbi.nlm.nih.gov/pubmed/?term=Cameselle%20JC%5BAuthor%5D&cauthor=true&cauthor_uid=25692488> have revised pathways for Reactome.

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute.Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the Reactome website<http://www.reactome.org/>.

Follow us on Twitter: @reactome<https://twitter.com/reactome> to get frequent updates about new and updated pathways, feature updates, and more!

For more information please contact Robin Haw<mailto:robin.haw at oicr.on.ca> (Tel: 647-260-7985).





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