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[go-friends] Reactome Announcement: Version 57 of Reactome Knowledgebase has been released.

Robin Haw Robin.Haw at
Thu Jul 7 11:27:08 PDT 2016



Version 57 Released

New Pathways for Version 57. Topics with new or revised pathways include: Developmental biology (RET signaling<>), Disease (Signaling by FGFR in disease<> and Defective CFTR causes cystic fibrosis<>), Gene expression (rRNA modification in the mitochondrion<> and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors<>), Immune system (ER-Phagosome pathway<>, Interleukin-7 signaling<>, Regulation by endogenous TLR ligand<>, and TCR signaling<>), Metabolism (Lipid digestion, mobilization, and transport<> and Phosphate bond hydrolysis by NTPDase proteins<>). Metabolism of proteins (Deubiquitination<>), Neuronal system (Interactions of neurexins and neuroligins at synapses<> and SALM protein interactions at <> synapse<>). Signal transduction (EGFR downregulation<>, Signaling by FGFR1<>, and FGFRL1 modulation of FGFR1 signaling<>), Transmembrane transport of small molecules (ABC-family proteins mediated transport<>) and Vesicle-mediated transport (Clathrin-mediated endocytosis<>).

Thanks to our Contributors. Our external author is Alba <> Sanchis<>. Costin Antonescu<>, John Bergeron<>, Daniel Bogenhagen<>, Nunzio Bottini<>, Guang-Chao Chen<>, Igor Dawid<>, Regina Fluhrer<>, Noriko Gotoh<>, Francesca Granucci<>, Richard Grose<>, Paul Heppenstall<>, Jing Hu<>, Jan Huertas<>, Wenqin Luo<>, Malay Mandal<>, Birgit <> Meldal<>, Daniel Morales<>, Tatsunori Nishimura<>, Ronald Petralia<>, Gail Seabold<>, Sunny Sharma<>, Stephanie Stanford<>, Jean Sévigny<>, Philip Washbourne<>, Ivan Zanoni<>, and Valeria Zarelli<> are our external reviewers.

Reactome comprises 9,865 human reactions organized into 2,034 pathways involving 9,622 proteins encoded by 8,695 different human genes, and 1,679 small molecules. These annotations are supported by xx,xxx literature references. We have projected these reactions onto 105,747 orthologous proteins, creating 19,793 orthologous pathways in 18 non-human species.

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, New York University Medical Center, and The European Bioinformatics Institute.Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the Reactome website<>.

Follow us on Twitter: @reactome<> to get frequent updates about new and updated pathways, feature updates, and more!

For more information, please contact our helpdesk<mailto:help at>.

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