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[go-friends] Reactome Announcement: Version 56 of Reactome Knowledgebase has been released.

Robin Haw Robin.Haw at
Thu Mar 31 11:11:16 PDT 2016

[Reactome Pathway Knowledgeable]<>

[Signaling by MST1 Pathway]<>
Version 56 Released

Topics with new or revised content in V56 include Cell cycle (AURKA activation by TPX2<>, Interaction between PHLDA1 and AURKA<>, and The role of GTSE1 in G2/M progression after G2 checkpoint<>) , Disease (Diseases associated with O-glycosylation of proteins<>), Gene  expression (ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression<>, Major pathway of rRNA processing in the nucleus<>, RNA polymerase II transcribes snRNA genes<>, rRNA modification in the nucleus<>, and Transcriptional Regulation by TP53<>), Immune system (Signaling by Interleukins and related cytokines<>), Metabolism<>,  Metabolism of proteins (Cooperation of PDCL and TRiC/CCT in G-protein beta folding<>), Neuronal system (SALM protein interactions at synapse<>), and signal transduction (Amine ligand-binding receptors<>, Chemokine receptors bind chemokines<>, ERBB2 regulates cell motility<>, FGFR2 alternative splicing<>, G alpha (s) signaling events<>, PI5P, PP2A and IER3 regulate AKT signaling<>, and Signaling by PTK6<>).

Our external reviewers are Ali Badache<>, Alexander Bird<>, Helen Chen<>, Richard P Grose<>, Hiren J Joshi<>, Lars Hansen<>, Nouria Hernandez<>, Sebastian Iben<>, Alberto Inga<>, Eunjoon Kim<>, Erin J Adams<>, Adrienne Luoma<>,Christopher A Maxwell<>, Birgit Meldal<>,  Isabel Pires<>, Francoise Porteu<>, Robin Reed<>, Ana Rondon<>,Kavita Shah<>, Sunny Sharma<>, Nicholas G Vincent<>, Karen Vousden<>, Barry M Willardson<>, Stuart A Wilson<>, Sara Zachary<>, and Dirk Zajonc<>.

The Reactome database comprises 9,584 human reactions organized into 1,937 pathways involving 9,483 proteins encoded by 9,245 different human genes, and 1,665 small molecules. These annotations are supported by 22,838 literature references. We have projected these reactions onto 100,852 orthologous proteins, creating 19,420 orthologous pathways in 18 non-human species.

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute.Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the Reactome website<>.

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