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[go-friends] EC2GO mapping changes

Harold Drabkin Harold.Drabkin at
Thu Oct 27 13:59:53 PDT 2016

The EC2GO mapping file is generated automatically from the GO ontology file using EC ids in term xrefs. This was implemented around 6-5-2014.
However, due to the ontology structure, if an xref had an EC id with a dash (a class term) , then that id would map to that go term and any of it's children.
This resulted in some ec ids generating many superfluous GO term mappings .
An examples:
MGI: Heph: EC.1.-; this maps to "enzyme" and then we get hundreds annotations from descendants.
MGI: Pus1: had EC: 5.4.99.-, gave mappings to all of these enzyme activities (, assuming the GO term for them existed.

So, the decision was made to by the ontology editors to remove an xref to EC that had a dash in it. This is an intended change.

For mgi, this reduced the number of IEAs for EC2GO from over 17,000 to a little over 900, but we weren't upset about them.

If you use this file you may note a similar drop

Harold J Drabkin, Ph.D.
Senior Scientific Curator
Mouse Genome Informatics
The Jackson Laboratory
600 Main Street
Bar Harbor, ME 04609
fax: 207-288-6830
Email: harold.drabkin at<mailto:harold.drabkin at>

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