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[go-friends] Obsoletion notice GO:0075147 regulation of signal transduction in response to host` & children

Pascale Gaudet pascale.gaudet at sib.swiss
Mon Oct 21 02:28:02 PDT 2019


Dear all, 


The proposal has been made to obsolete GO:0075147 regulation of signal transduction in response to host` and its children: 
'modulation of symbiont adenylate cyclase-mediated signal transduction in response to host'
'negative regulation of G protein-coupled receptor signaling pathway in response to host'
'negative regulation of G-protein alpha subunit-mediated signal transduction in response to host'
'negative regulation of G-protein beta subunit-mediated signal transduction in response to host'
'negative regulation of G-protein gamma subunit-mediated signal transduction in response to host'
'negative regulation of MAP kinase-mediated signal transduction in response to host'
'negative regulation of cAMP-mediated signaling in response to host'
'negative regulation of calcium or calmodulin-mediated signal transduction in response to host'
'negative regulation of protein kinase-mediated signal transduction in response to host'
'negative regulation of receptor-mediated signal transduction in response to host'
'negative regulation of signal transduction in response to host'
'negative regulation of symbiont adenylate cyclase-mediated signal transduction in response to host'
'negative regulation of transmembrane receptor-mediated cAMP signal transduction in response to host'
'negative regulation of transmembrane receptor-mediated signal transduction in response to host'
'positive regulation of G protein-coupled receptor signaling pathway in response to host'
'positive regulation of G-protein alpha subunit-mediated signal transduction in response to host'
'positive regulation of G-protein beta subunit-mediated signal transduction in response to host'
'positive regulation of G-protein gamma subunit-mediated signal transduction in response to host'
'positive regulation of MAP kinase-mediated signal transduction in response to host'
'positive regulation of cAMP-mediated signaling in response to host'
'positive regulation of calcium or calmodulin-mediated signal transduction in response to host'
'positive regulation of receptor-mediated signal transduction in response to host'
'positive regulation of signal transduction in response to host'
'positive regulation of symbiont adenylate cyclase-mediated signal transduction in response to host'
'positive regulation of symbiont protein kinase-mediated signal transduction in response to host'
'positive regulation of transmembrane receptor-mediated cAMP signal transduction in response to host'
'positive regulation of transmembrane receptor-mediated signal transduction in response to host'
'regulation of G protein-coupled receptor signaling pathway in response to host'
'regulation of G-protein alpha subunit-mediated signal transduction in response to host'
'regulation of G-protein beta subunit-mediated signal transduction in response to host'
'regulation of G-protein gamma subunit-mediated signal transduction in response to host'
'regulation of MAP kinase-mediated signal transduction in response to host'
'regulation of cAMP-mediated signaling in response to host'
'regulation of calcium or calmodulin-mediated signal transduction in response to host'
'regulation of protein kinase-mediated signal transduction in response to host'
'regulation of receptor-mediated signal transduction in response to host'
'regulation of transmembrane receptor-mediated cAMP signaling in response to host'
'regulation of transmembrane receptor-mediated signal transduction in response to host'


The reason for obsoletion is that these terms are supposed to represent symbiontic processes, but the processes here only occur in eukaryotes. 

There are only two annotations to ‘regulation of calcium or calmodulin-mediated signal transduction in response to host' to a single tomato gene (SGN:9783), based on PMID:23621884, which describes resistance to plant pathogens, so the annotations should be moved to 'defense response to bacteria' and 'defense response to fungus’ (ie, this is NOT a response to the host, it’s a response BY the host). 

Any comments can be added to the issue: https://github.com/geneontology/go-ontology/issues/18010 <https://github.com/geneontology/go-ontology/issues/18000>

We are opening a comment period for this proposed obsoletion. We’d like to proceed and obsolete this term on October 25th, 2019. Unless objections are received by October 25th  2019, we will assume that you agree to this change.

Thanks, Pascale




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