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[go-friends] Obsoletion notice: 'GO:0052470 modulation by host of symbiont signal transduction pathway' and children

Pascale Gaudet pascale.gaudet at sib.swiss
Mon Sep 9 08:02:31 PDT 2019


Dear all,

The proposal has been made to obsolete 'GO:0052470 modulation by host of symbiont signal transduction pathway' and children.

The reason for obsoletion is that there is no evidence that the host can modulate or regulate a symbiont's signal transduction pathway. There are 4 experimental annotations to these terms (annotation review ticket: geneontology/go-annotation#2650 <https://github.com/geneontology/go-annotation/issues/2650>).
There are no mappings; these terms are not in any subsets (slims).

The terms are:

GO:0052470 modulation by host of symbiont signal transduction pathway >1 annotation PAMGO_MGG
GO:0075099 modulation by host of symbiont protein kinase-mediated signal transduction
GO:0052435 modulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
GO:0075102 negative regulation by host of symbiont MAP kinase-mediated signal transduction
GO:0075101 negative regulation by host of symbiont protein kinase-mediated signal transduction
GO:0052502 positive regulation by host of defense-related symbiont MAP kinase-mediated signal transduction pathway
GO:0075100 positive regulation by host of symbiont protein kinase-mediated signal transduction
GO:0075103 modulation by host of symbiont calcium or calmodulin-mediated signal transduction
GO:0052492 negative regulation by host of symbiont signal transduction pathway
GO:0043962 negative regulation by host of symbiont adenylate cyclase-mediated signal transduction
GO:0075105 negative regulation by host of symbiont calcium or calmodulin-mediated signal transduction
GO:0075104 positive regulation by host of symbiont calcium or calmodulin-mediated signal transduction
GO:0075333 positive regulation by host of symbiont adenylate cyclase-mediated signal transduction
GO:0075206 positive regulation by host of symbiont cAMP-mediated signal transduction -> 3 annotations CAFA x ray paper
GO:0052493 negative regulation by organism of signal transduction in other organism involved in symbiotic interaction
GO:0052526 positive regulation by organism of signal transduction in other organism involved in symbiotic interaction
GO:0075087 modulation by host of symbiont G protein-coupled receptor signal transduction
GO:0075332 modulation by host of symbiont adenylate cyclase-mediated signal transduction
GO:0075205 modulation by host of symbiont cAMP-mediated signal transduction
GO:0075078 modulation by host of symbiont receptor-mediated signal transduction
GO:0075090 modulation by host of symbiont signal transduction mediated by G-protein alpha subunit
GO:0075093 modulation by host of symbiont signal transduction mediated by G-protein beta subunit
GO:0075096 modulation by host of symbiont signal transduction mediated by G-protein gamma subunit
GO:0075084 modulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
GO:0075081 modulation by host of symbiont transmembrane receptor-mediated signal transduction
GO:0075089 negative regulation by host of symbiont G protein-coupled receptor signal transduction
GO:0075207 negative regulation by host of symbiont cAMP-mediated signal transduction
GO:0075080 negative regulation by host of symbiont receptor-mediated signal transduction
GO:0075080 negative regulation by host of symbiont signal transduction mediated by G-protein alpha subunit
GO:0075095 negative regulation by host of symbiont signal transduction mediated by G-protein beta subunit
GO:0075098 negative regulation by host of symbiont signal transduction mediated by G-protein gamma subunit
GO:0075086 negative regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
GO:0075083 negative regulation by host of symbiont transmembrane receptor-mediated signal transduction
GO:0075088 positive regulation by host of symbiont G protein-coupled receptor signal transduction
GO:0075079 positive regulation by host of symbiont receptor-mediated signal transduction
GO:0075091 positive regulation by host of symbiont signal transduction mediated by G-protein alpha subunit
GO:0075094 positive regulation by host of symbiont signal transduction mediated by G-protein beta subunit
GO:0075097 positive regulation by host of symbiont signal transduction mediated by G-protein gamma subunit
GO:0052525 positive regulation by host of symbiont signal transduction pathway
GO:0075085 positive regulation by host of symbiont transmembrane receptor-mediated cAMP signal transduction
GO:0075082 positive regulation by host of symbiont transmembrane receptor-mediated signal transduction
Any comments can be added to the issue: https://github.com/geneontology/go-ontology/issues/ <https://github.com/geneontology/go-ontology/issues/>17811

We are opening a comment period for this proposed obsoletion. We’d like to proceed and obsolete this term on September 13th. Unless objections are received by September 13th, we will assume that you agree to this change.
Thanks, Pascale

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