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[go-friends] Gene Ontology Causal Activity Models (GO-CAMs) paper out

Chris Mungall cjmungall at lbl.gov
Mon Sep 30 13:42:43 PDT 2019


Hi all,

We have a new paper out describing GO-CAMs!

*Gene Ontology Causal Activity Modeling (GO-CAM) moves beyond GO
annotations to structured descriptions of biological functions and
systems *(2019),
Thomas et al, *Nat Gen* http://rdcu.be/bRIgY

A GO-CAM model is a combination of standard GO annotations to produce a
network of annotations (“model”), that is a more complete model of
biological function than the separate annotations. For example, a GO-CAM
can represent how the activities of different gene products work together
in a pathway or “biological program.” GO-CAM models can connect different
pieces of information about the function of a gene product (joining
together different annotations for the same gene product), and/or can
connect functions of different gene products together by specifying how the
activity of one gene product can affect the activity of another gene
product.

This can be seen in the example below (a) is traditional annotation, (b) is
GO-CAM

[image: image.png]

Find out more on the link at the bottom here:
http://geneontology.org
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