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[go-friends] Merge 'GO:0007050 cell cycle arrest' and children

Pascale Gaudet Pascale.Gaudet at sib.swiss
Wed Mar 3 02:10:03 PST 2021


Hello again,

Here's the list of EXP annotations:
https://docs.google.com/spreadsheets/d/1vdei_8YbKKbgHHlPF-9LNQw10CKHwjbdE-09__-RasY/edit#gid=0

Contributor (Assigned by)
BHF-all
46
CACAO
7
CAFA
4
ComplexPortal
1
FlyBase
3
5
MGI
26
ParkinsonsUK-UCL
3
RGD
6
SGD
2
TAIR
2
UniProt
72
WB
12
ZFIN
1



Thanks, Pascale

From: Pascale Gaudet <Pascale.Gaudet at sib.swiss>
Date: Wednesday, 3 March 2021 at 10:56
To: "go-friends at lists.stanford.edu" <go-friends at mailman.stanford.edu>
Subject: Merge 'GO:0007050 cell cycle arrest' and children

Dear all,

The following terms will be merged into 'GO:0051726 regulation of cell cycle'.

GO:0007050 cell cycle arrest
GO:0071850 mitotic cell cycle arrest
GO:0071156 regulation of cell cycle arrest
GO:0071157 negative regulation of cell cycle arrest
GO:0071158 positive regulation of cell cycle arrest

The reason for this change is that 'cell cycle arrest' is a measure of the cell cycle status, not a process in itself. In several instances, the genes annotated to cell cycle arrest are causing a pathological situation in the cell resulting activation of a cell cycle checkpoint; this does not mean that the genes are involved in cell cycle signaling in a normal situation. We have noticed several examples where cell cycle arrest is a phenotype, and the paper lack evidence that the gene is involved in cell cycle regulation.

There are 186 EXP annotations to the 5 terms mentioned above.
When reviewing annotations, if there is sufficient evidence for a role in cell cycle progression or exit from the cell cycle (G0), these terms can be considered for replacement:

GO:0000075 cell cycle checkpoint signaling or a descendant
GO:0070314 G1 to G0 transition
GO:0070315 G1 to G0 transition involved in cell differentiation

An 'easier' option would be to use the relation 'causally upstream of or within'.

Thanks, Pascale & Val
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