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[go-friends] Obsoletion notice: GO:0016458 gene silencing, GO:0060968 regulation of gene silencing, GO:0060969 negative regulation of gene silencing

Pascale Gaudet Pascale.Gaudet at
Fri Sep 24 08:12:59 PDT 2021

Dear all,

The proposal has been made to obsolete
GO:0016458 gene silencing
GO:0060968 regulation of gene silencing
GO:0060969 negative regulation of gene silencing
(note that there is no 'positive regulation' term).

The reason for obsoletion is that this term is broadly defined (as described in the comment "This is a rather broad grouping term. While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class." ) and its definition is not clearly distinct from that of 'GO:0045814 negative regulation of gene expression, epigenetic'.

GO:0016458 gene silencing  is in 2 subsets:
goslim_drosophila @hattrill
goslim_pir @nataled
This can be moved to
* GO:0010629 negative regulation of gene expression
* GO:0031507 heterochromatin assembly and  GO:0031047 gene silencing by RNA, represent the 2 broad mechanisms of gene silencing.

There are no mappings to these terms.

There are 86 annotations:

Contributor   (Assigned by) | Number of annotations
AspGD | 1
FlyBase | 27
GeneDB | 2
GO_Central | 2
MGI | 5
SGD | 5
TAIR | 16
UniProt | 22
WB | 2
ZFIN | 3

We are opening a comment period for this proposed obsoletion. We’d like to proceed and obsolete this term on October 8th, 2021. Unless objections are received by 10/8/21, we will assume that you agree to this change.

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