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<div><a href="http://www.reactome.org/PathwayBrowser/#DIAGRAM=5358346&PATH=162582,5358351" data-mce-href="http://www.reactome.org/PathwayBrowser/#DIAGRAM=5358346&PATH=162582,5358351" style="font-family: Georgia, 'Times New Roman', 'Bitstream Charter', Times, serif; font-size: 13px; line-height: 19px; text-align: justify; background-color: rgb(255, 255, 255);"><img class="alignnone wp-image-2461" alt="Hhg" width="640" height="157" data-mce-src="http://reactomedev.oicr.on.ca/wordpress/wp-content/uploads/2014/07/Hhg-1024x251.jpg" data-wp-imgselect="1" data-mce-selected="1" style="outline: rgb(119, 119, 119) solid 1px; resize: none;" apple-inline="yes" id="D6B36088-9789-45BB-99DC-4EFDC702BBDB" apple-width="yes" apple-height="yes" src="cid:7E541666-9655-4E78-9C59-E65BF809FA50@phub.net.cable.rogers.com"></a></div>
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<strong>New for Release 49: </strong>Disease pathways have been expanded to include <a href="http://www.reactome.org/PathwayBrowser/#REACT_228331" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228331">WNT in cancer</a>, <a href="http://www.reactome.org/PathwayBrowser/#REACT_228255" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228255">Uptake
 and function of anthrax toxins</a>, and <a href="http://www.reactome.org/PathwayBrowser/#REACT_228190" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228190">Processing-defective Hh variants abrogate ligand secretion</a>. Metabolism now includes <a href="http://www.reactome.org/PathwayBrowser/#REACT_228214" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228214">Aflatoxin
 activation and detoxification</a>, and Immune system covers <a href="http://www.reactome.org/PathwayBrowser/#REACT_25148" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_25148">Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon</a>. Development
 has been updated with <a href="http://www.reactome.org/PathwayBrowser/#REACT_228170" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228170">EPH-EFN signaling</a>. New pathways under Signal Transduction include <a href="http://www.reactome.org/PathwayBrowser/#REACT_200777" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_200777">TCF-dependent
 signaling in response to WNT</a>, <a href="http://www.reactome.org/PathwayBrowser/#REACT_228166" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228166">VEGFA-VEGFR2 signaling</a>, and <a href="http://www.reactome.org/PathwayBrowser/#REACT_228134" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228134">Hedgehog
 ligand biogenesis</a>. <a href="http://www.reactome.org/PathwayBrowser/#REACT_228013" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228013">Mismatch Repair</a> has been added to DNA repair, and Chromatin Organization has been expanded to cover <a href="http://www.reactome.org/PathwayBrowser/#REACT_228222" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228222">HDACs
 deacetylate histones</a>, <a href="http://www.reactome.org/PathwayBrowser/#REACT_228108" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228108">RMTs methylate histone arginines</a>, and <a href="http://www.reactome.org/PathwayBrowser/#REACT_228178" data-mce-href="http://www.reactome.org/PathwayBrowser/#REACT_228178">HDMs
 demethylate histones</a>. Wed like to thank our external contributors. <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Kikuchi%20A%5BAuthor%5D&cauthor=true&cauthor_uid=24562386" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Kikuchi%20A%5BAuthor%5D&cauthor=true&cauthor_uid=24562386">Akira
 Kikuchi</a> is our external author. <a href="http://www.psi.ch/lbr/ballmer_-kurt" data-mce-href="http://www.psi.ch/lbr/ballmer_-kurt">Kurt Ballmer</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Philipp+Berger" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Philipp+Berger">Philipp
 Berger</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Michael%20A%20Edelbrock%5BAuthor%5D" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Michael%20A%20Edelbrock%5BAuthor%5D">Michael Edelbrock</a>, <a href="http://www.imcb.a-star.edu.sg/php/eg.php" data-mce-href="http://www.imcb.a-star.edu.sg/php/eg.php">Ernesto
 Guccione</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Richard%20Hopkinson" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Richard%20Hopkinson">Richard Hopkinson</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Nancy%20Y%20Ip%5BAuthor%5D" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Nancy%20Y%20Ip%5BAuthor%5D">Nancy
 Ip</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Stephen%20H%20Leppla%5BAuthor%5D" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Stephen%20H%20Leppla%5BAuthor%5D">Stephen Leppla</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Shihui%20Liu%5BAuthor%5D" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Shihui%20Liu%5BAuthor%5D">Shihui
 Liu</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Liu%20YC%5BAuthor%5D&cauthor=true&cauthor_uid=22319451" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Liu%20YC%5BAuthor%5D&cauthor=true&cauthor_uid=22319451">Yulu Liu</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Masci%20AM%5BAuthor%5D&cauthor=true&cauthor_uid=23326591" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Masci%20AM%5BAuthor%5D&cauthor=true&cauthor_uid=23326591">Anna
 Maria Masci</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Mahtab%20Moayeri%5BAuthor%5D" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Mahtab%20Moayeri%5BAuthor%5D">Mahtab Moayeri</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Nishani%20Rajakulendran%5BAuthor%5D" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Nishani%20Rajakulendran%5BAuthor%5D">Nishani
 Rajakulendran</a>, <a href="http://www.salahshor.com/" data-mce-href="http://www.salahshor.com/">Sima Salahshor</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Schofield%20CJ%5BAuthor%5D&cauthor=true&cauthor_uid=24859458" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Schofield%20CJ%5BAuthor%5D&cauthor=true&cauthor_uid=24859458">Christopher
 Schofield</a>, <a href="http://www.yale.edu/turklab/" data-mce-href="http://www.yale.edu/turklab/">Benjamin E Turk</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Louise%20Walport%5BAuthor%5D" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Louise%20Walport%5BAuthor%5D">Louise
 Walport</a>, <a href="http://www.mcb.uu.se/res/groups/mw/" data-mce-href="http://www.mcb.uu.se/res/groups/mw/">Michael Welsh</a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Woodgett%20J%5BAuthor%5D&cauthor=true&cauthor_uid=22665058" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Woodgett%20J%5BAuthor%5D&cauthor=true&cauthor_uid=22665058">Jim
 Woodgett</a>, and <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Yang%20XJ%5BAuthor%5D&cauthor=true&cauthor_uid=23393134" data-mce-href="http://www.ncbi.nlm.nih.gov/pubmed?term=Yang%20XJ%5BAuthor%5D&cauthor=true&cauthor_uid=23393134">Xiang-Jiao Yang </a>are
 our external reviewers.</p>
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<strong>New Reactome Pathway Analysis Portal: </strong>In response to user feedback and new feature requests, we have released a new <a href="http://www.reactome.org/PathwayBrowser/" data-mce-href="http://www.reactome.org/PathwayBrowser/">Reactome Pathway Browser</a> with
 an integrated suite of tools for pathway analysis. Using these improved features, you can map protein lists to Reactome pathways, perform pathway overrepresentation analysis for a set of genes, colourize pathway diagrams with gene expression data, and compare
 model organism and human pathways. To support third-party tool integration, the <a href="http://www.reactome.org/PathwayBrowser/#TOOL=AT" data-mce-href="http://www.reactome.org/PathwayBrowser/#TOOL=AT">Reactome Pathway Analysis Portal</a> is also available
 via RESTful web services. Further details about the new pathway analysis tool can be found in our <a href="http://wiki.reactome.org/index.php/Usersguide" data-mce-href="http://wiki.reactome.org/index.php/Usersguide">User Guide</a>.</p>
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<strong>Feature Update - Molecules tab in the Pathway Browser: </strong>The Molecules tab in the <a href="http://www.reactome.org/PathwayBrowser/" data-mce-href="http://www.reactome.org/PathwayBrowser/">Pathway Browser</a> now has improved interactivity and
 usability, allowing users to easily list or download all molecule information from the currently displayed Pathway Diagram.</p>
<p data-mce-style="text-align: justify;" style="color: rgb(51, 51, 51); font-family: Georgia, 'Times New Roman', 'Bitstream Charter', Times, serif; font-size: 13px; line-height: 19px; text-align: justify;">
<strong>New Reactome Publications: </strong>Two new Reactome papers entitled <a href="http://database.oxfordjournals.org/content/2014/bau060.full?keytype=ref&ijkey=5vukyCbDLpzKSa2" data-mce-href="http://database.oxfordjournals.org/content/2014/bau060.full?keytype=ref&ijkey=5vukyCbDLpzKSa2">A
 controlled vocabulary for pathway entities and events</a> and <a href="http://f1000research.com/articles/3-146/" data-mce-href="http://f1000research.com/articles/3-146/">ReactomeFIViz: the Reactome FI Cytoscape app for pathway and network-based data analysis</a>
 have been published in <a href="http://database.oxfordjournals.org/" data-mce-href="http://database.oxfordjournals.org/">DATABASE</a> and <a href="http://f1000research.com/" data-mce-href="http://f1000research.com/">F1000Research</a>, respectively. More publications
 from the <a href="http://www.reactome.org/?page_id=581" data-mce-href="http://www.reactome.org/?page_id=581">Reactome Team</a> can be found <a href="http://www.reactome.org/?page_id=1001" data-mce-href="http://www.reactome.org/?page_id=1001">here</a>.</p>
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<strong>Important Dates: </strong> Members of the <a href="http://www.reactome.org/?page_id=581" data-mce-href="http://www.reactome.org/?page_id=581">Reactome Team</a> will be attending the <a href="http://www.febs-embo2014.org" data-mce-href="http://www.febs-embo2014.org">FEBS-EMBO
 2014</a> Meeting in Paris, France from 30 August  4 September, and the <a href="http://www.eccb14.org" data-mce-href="http://www.eccb14.org">ECCB14</a> Meeting in Strasbourg, France from 7-10 September.</p>
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<strong>Follow us on Twitter: </strong><a href="https://twitter.com/reactome" data-mce-href="https://twitter.com/reactome">@reactome</a> to get frequent updates about new and updated pathways, feature updates, and more!</p>
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Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute.Reactome data and software are distributed under the terms
 of the Creative Commons Attribution 3.0 Unported License. A full description of the new and updated content is available on the <a href="http://www.reactome.org" data-mce-href="http://www.reactome.org">Reactome website</a>.</p>
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For more information, contact: Robin Haw, help [at] <a href="http://reactome.org">
reactome.org</a>.</p>
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