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<a href="http://www.reactome.org/" class="wysija_image_link" style="color: rgb(74, 145, 176); word-wrap: break-word; height: 70px; width: 562px; outline: 0px; border: 0px; display: block; margin: 0px; padding: 0px;"><img width="562" height="70" src="http://reactomedev.oicr.on.ca/wordpress/wp-content/uploads/2015/03/reactome_news-600x77.png" border="0" alt="Reactome News Announcement" class="image_fix" style="outline: 0px; text-decoration: none; border: 0px; display: block; width: 562px; height: 70px;"></a></td>
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<a href="http://reactome.org/PathwayBrowser/#R-HSA-73894.2" class="wysija_image_link" style="color: rgb(74, 145, 176); word-wrap: break-word; height: 481px; width: 562px; outline: 0px; border: 0px; display: block; margin: 0px; padding: 0px;"><img width="562" height="481" src="http://reactomedev.oicr.on.ca/wordpress/wp-content/uploads/2015/10/DNA_Repair-600x514.png" border="0" alt="DNA Repair" class="image_fix" style="outline: 0px; text-decoration: none; border: 0px; display: block; width: 562px; height: 481px;"></a></div>
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<strong>New Pathways for Version 54.</strong> Th<span class="s1">e topic <span class="s2"><a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5205647" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">Mitophagy</a> </span>has
 been added. New disease pathways include <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5619102&PATH=1643685,5619115" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">
<span class="s2">SLC transporter disorders</span></a>, <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5662853&PATH=1643685,5668914,5663084" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Essential pentosuria</span></a>, <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5687613&PATH=1643685,5668914" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Diseases
 associated with surfactant metabolism</span></a>,  <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=6791465&PATH=1643685,5668914,5663084" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Pentose phosphate
 pathway disease</span></a>, and <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=3229121&PATH=1643685,5668914,5663084" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Glycogen storage diseases</span></a>.
 Updated DNA repair pathways include <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5693532&PATH=73894" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Double-strand break repair</span></a>, <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5696398&PATH=73894" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Nucleotide
 excision repair</span></a>, and the <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=6783310&PATH=73894" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Fanconi anemia pathway</span></a>. Gene expression
 now covers <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=72306&PATH=74160" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">tRNA processing</span></a> and immune system annotations have been expanded
 to include <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5684264&PATH=168256,1280215,449147,446652" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">MAP3K8 (TPL2)-dependent MAPK1/3 activation</span></a> as
 well as updates to the <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=198933&PATH=168256,1280218" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Immunoregulatory interactions between a lymphoid and a
 non-lymphoid cell</span></a> pathway. Under Metabolism, <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5683826&PATH=392499" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Surfactant metabolism</span></a> and <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=71387&ID=5661270&PATH=1430728" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Catabolism
 of glucuronate to xylulose-5-phosphate</span></a> have been added and <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=71387&ID=5652084&PATH=1430728" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Fructose
 metabolism</span></a> has been revised. Metabolism of proteins includes additions to the <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=977225&PATH=392499" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Amyloid
 formation</span></a> pathway. Signal transduction includes updates to the <span class="s2"><a href="http://reactome.org/PathwayBrowser/#DIAGRAM=75893&PATH=162582,73887" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">TNF signaling</a> </span>pathway
 and Vesicle-mediated transport now covers <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=5694530&PATH=5653656,199991,199977" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Cargo concentration in the
 ER</span></a> as well as additions to <span class="s2"><a href="http://reactome.org/PathwayBrowser/#DIAGRAM=204005&PATH=5653656,199991,199977" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">COPII (Coat protein 2) mediated
 vesicle transport.</a> </span></span></p>
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<span class="s3">New pathway Illustrations are available for <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=446203&PATH=392499,597592" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s4">Asparagine N-linked
 glycosylation</span></a> and <a href="http://reactome.org/PathwayBrowser/#DIAGRAM=73894" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s4">DNA repair</span></a>.</span></p>
<p align="justify" style="font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 13px; line-height: 19.5px; margin: 1em 0px; padding: 0px; border: 0px; vertical-align: top; word-wrap: break-word;">
<span class="s3"><a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Alexander%20%20%20Barrow%5BAuthor%20-%20Full%5D" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">Alexander Barrow</a></span><span class="s1">, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=James+Borowiec%5BAuthor+-+Full%5D" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">James
 Borowiec</span></a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Br%C3%B6er%20S%5BAuthor%5D&cauthor=true&cauthor_uid=26240152" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Stefan Brer</span></a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Chauss%20D%5BAuthor%5D&cauthor=true&cauthor_uid=20888813" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Daniel
 Chauss</span></a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=DeCicco-Skinner%20KL%5BAuthor%5D&cauthor=true&cauthor_uid=25225985" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Katie DeCicco-Skinner</span></a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Maria+Fousteri" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Maria
 Fousteri</span></a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Kasper+Fugger" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Kasper Fugger</span></a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Marc%20Kantorow%5BAuthor%20-%20Full%5D" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Marc
 Kantorow</span></a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Louis%20Levinger%5BAuthor%20-%20Full%5D" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Louis Levinger</span></a>, <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Yuri%20%20Motorin%5BAuthor%20-%20Full%5D" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Yuri
 Motorin</span></a>, and <a href="http://www.ncbi.nlm.nih.gov/pubmed?term=Harald%20Wajant%5BAuthor%20-%20Full%5D" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;"><span class="s2">Harald Wajant</span></a> are our external reviewers<strong>. </strong><span class="s2"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Ribeiro%20JM%5BAuthor%5D&cauthor=true&cauthor_uid=25692488" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">Joo
 Ribeiro</a> </span>and <span class="s2"><a href="http://www.ncbi.nlm.nih.gov/pubmed/?term=Cameselle%20JC%5BAuthor%5D&cauthor=true&cauthor_uid=25692488" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">Jos Carlos Cameselle</a> </span>have
 revised pathways for Reactome.</span></p>
<p align="justify" style="font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 13px; line-height: 19.5px; margin: 1em 0px; padding: 0px; border: 0px; vertical-align: top; word-wrap: break-word;">
<span style="font-family: arial, helvetica, sans-serif;">Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Cold Spring Harbor Laboratory, New York University Medical Center, and The European Bioinformatics Institute.Reactome
 data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the <a href="http://www.reactome.org/" target="_blank" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">Reactome
 website</a>.</span></p>
<p align="justify" style="font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 13px; line-height: 19.5px; margin: 1em 0px; padding: 0px; border: 0px; vertical-align: top; word-wrap: break-word;">
<strong>Follow us on Twitter: </strong><a href="https://twitter.com/reactome" target="_blank" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">@<span class="il">reactome</span></a> to get frequent updates about new and updated
 pathways, feature updates, and more!</p>
<p align="justify" style="font-family: Arial, 'Helvetica Neue', Helvetica, sans-serif; font-size: 13px; line-height: 19.5px; margin: 1em 0px; padding: 0px; border: 0px; vertical-align: top; word-wrap: break-word;">
For more information please contact <a href="mailto:robin.haw@oicr.on.ca" style="word-wrap: break-word; border: 0px; color: rgb(74, 145, 176) !important;">Robin Haw</a> (Tel: 647-260-7985).</p>
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