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gene of the quarter

Evelyn Camon camon at ebi.ac.uk
Wed Jan 31 03:33:42 PST 2007


Hi,

You may also be interested in this page for Interpro and Expasy proteins 
of the month:-)))...Swiss-Prot is also trying to launch an 'adopt a 
protein' scheme starting of with yeast proteins i believe....

http://www.ebi.ac.uk/interpro/potm/archive.html

http://www.expasy.org/spotlight/

cheers
Evelyn

Tanya Berardini wrote:
> Also, PDB has molecule of the month:
> 
> http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html 
> 
> 
> But it is quite involved.
> 
> Tanya
> 
> 
> Jane Lomax wrote:
> 
>> For reference, ChEBI do a nice 'entity of the month':
>>
>> http://www.ebi.ac.uk/chebi/
>>
>> although we might need something a bit shorter...
>>
>> jane
>>
>> On Tue, 30 Jan 2007, Susan Tweedie wrote:
>>
>>> On Tue, 2007-01-30 at 14:42 +0000, Valerie Wood wrote:
>>>
>>>> Here is something that is fairly recent and of broad interest. In
>>>> addition to the functional characterisation the work identified the
>>>> orthology between human Cernunnos and NEJ1 in yeast.
>>>>
>>>>
>>>> XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA 
>>>> nonhomologous end-joining.
>>>>
>>>> Ahnesorg P, Smith P, Jackson SP;
>>>> Cell. 2006;124:301-313.
>>>> PMID: 16439205
>>>>
>>>> Cernunnos
>>>> interacts with the XRCC4 x DNA-ligase IV complex and is homologous to
>>>> the yeast nonhomologous end-joining factor Nej1.
>>>> Callebaut I, Malivert L, Fischer A, Mornon JP, Revy P, de Villartay JP;
>>>>
>>>> J Biol Chem. 2006;281:13857-13860.
>>>> PMID: 16571728
>>>> Cavero S, Chahwan C, Russell P.
>>>> Xlf1 is required for DNA repair by nonhomologous end-joining in 
>>>> Schizosaccharomyces pombe.
>>>>
>>>> Genetics. 2006 Dec 6; PMID: 17151234 -
>>>>
>>>>  From this we were able to create a protein family
>>>> http://www.sanger.ac.uk/cgi-bin/Pfam/getacc?PF09302
>>>>
>>>> You can see from the alignment how distant the orthology is. None of 
>>>> the
>>>> orthology detectors pick up divergent orthologs like this, so its also
>>>> interesting from a functional transfer of annotation perspective.
>>>>
>>>>
>>>> I'm not volunteering to write it but I'd be willing to ask if any of 
>>>> the
>>>> labs working on it would like to......
>>>
>>>
>>> Sounds like a good subject. It would be great if you could find someone
>>> working in the field to write it - we'd give them a byline! I realise it
>>> is short notice though and I wouldn't want them to go to town too much
>>> since space it limited.
>>>
>>> Susan
>>>
>>>>
>>>> Val
>>>>
>>>>
>>>>
>>>>
>>>>
>>>>
>>>> Susan Tweedie wrote:
>>>>
>>>>> In the last issue of the GO newsletter we promised a 'Gene of the
>>>>> Quarter' item to highlight progress on the ref genome project.
>>>>>
>>>>> Does anyone have any suggestions for a good gene to choose, ideas of
>>>>> what to include or better still would like to volunteer to write a 
>>>>> short
>>>>> item (200-250 words)? We aim to get the next edition out mid-Feb so
>>>>> would appreciate a quickish response.
>>>>>
>>>>> Thanks,
>>>>>
>>>>> Susan (on behalf of the GO newsletter team)
>>>>>
>>>>>
>>>>
>>>>
>>>
>>
>> Dr Jane Lomax
>> GO Editorial Office
>> EMBL-EBI
>> Wellcome Trust Genome Campus
>> Hinxton
>> Cambridgeshire, UK
>> CB10 1SD
>>
>> p: +44 1223 492516
>> f: +44 1223 494468
> 
> 


-- 
Evelyn Camon
GOA Coordinator
Senior Scientific Curator
European Bioinformatics Institute
Tel:01223-494465
Fax:01223-494468
E-mail: camon at ebi.ac.uk
URL: http://www.ebi.ac.uk/goa




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